Results 51 to 60 of about 13,799 (205)

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Whole Exome Sequencing Identified a Novel Mutation in the LOXHD1 Gene in Consanguineous Iranian Families With Hearing Loss

Journal of Clinical Laboratory Analysis, EarlyView.
Whole exome sequencing in a consanguineous Iranian family with autosomal recessive non‐syndromic hearing loss revealed a novel homozygous frameshift mutation, c.3713dupA (p.Asp1238Glufs*10), in the LOXHD1 gene. This mutation, located in exon 24, results in a premature stop codon and a truncated protein. Sanger sequencing confirmed co‐segregation of the
Solmaz Hassani Fard Katiraei, Milad Gholami, Mohsen Soosanabadi, Mona Entezam, Seyed Alireza Dastgheib   +4 more
wiley   +1 more source

Relationship Between Serum Ferritin Level and Amikacin Ototoxicity

Oman Medical Journal, 2012
Objectives: Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. One of the theories in aminoglycosides ototoxicity is that Iron-aminoglycoside complex causes ototoxicity by ...
Mohammad Shayaninasab, Mohammadreza Fatololoomi, Fatollah Behnood, Azam Alizamir   +3 more
doaj  

Ménière's Disease: A Tri‐Decade Scoping Review of Treatment Trends and Evidence Quality

The Laryngoscope, EarlyView.
This tri‐decade scoping review of Ménière's disease literature reveals a significant increase in high‐level evidence and a clinical pivot toward hearing‐preserving interventions, such as intratympanic steroids and cochlear implants. However, a significant quality paradox has emerged, where adherence to standardized AAO‐HNS reporting and diagnostic ...
Ofir Zavdy, Teeraya Piyajarawong, Seamus Boyle, Ross O'Shea, John Rutka   +4 more
wiley   +1 more source

Early detection of platinum-induced ototoxicity in adults

B-ENT, 2017
Early detection of platinum-induced ototoxicity in adults. Problems/objectives: Multiple toxicities, including ototoxicity, have been reported for patients treated with the widely used, anti-solid tumour agent, cisplatin.
E. D’heygere, R. Kuhweide, H. Pottel, L. Mus, T. Vauterin, Bob Lerut   +5 more
doaj   +2 more sources

Which Environmental Pollutants Are Toxic to Our Ears?—Evidence of the Ototoxicity of Common Substances

Toxics
Ototoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the ...
Gregory M. Zarus, Patricia Ruiz, Rae Benedict, Stephan Brenner, Krystin Carlson, Layna Jeong, Thais C. Morata   +6 more
doaj   +1 more source

Protective Effects of Glucose-Related Protein 78 and 94 on Cisplatin-Mediated Ototoxicity

Antioxidants, 2020
Cisplatin is a widely used chemotherapeutic drug for treating various solid tumors. Ototoxicity is a major dose-limiting side effect of cisplatin, which causes progressive and irreversible sensorineural hearing loss.
Junyeong Yi, Tae Su Kim, Jhang Ho Pak, Jong Woo Chung   +3 more
doaj   +1 more source

Multicenter Study Results on Expanded Indications in Med‐EL Pediatric Cochlear Implant Population

The Laryngoscope, EarlyView.
ABSTRACT Objectives To demonstrate safety and efficacy of MED‐EL cochlear implants (CIs) in children aged < 12 months and in children aged 12–71 months with residual hearing. Methods This was a multicenter, nonrandomized, single‐subject, repeated‐measures study with prospective (N = 38; 26 < 12 months of age) and retrospective (N = 209; 70 < 12 months ...
Nancy M. Young, Denise Thomas, Stephen R. Hoff, Jeffrey D. Carron, Victoria B. Gonzalez, Chrisanda M. Sanchez, Ivette Cejas, Paul W. Bauer, Aimee J. Gross, Margaret E. Richter, Lisa R. Park, Kevin D. Brown   +11 more
wiley   +1 more source

Effects of Asymmetric Auditory Deprivation in Sequential Cochlear Implant

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the influence of auditory deprivation on sequential cochlear implants in postlingual patients, comparing the ear with shorter deprivation (ESAD), longer deprivation (ELAD), and the bilateral condition (BIL). Study design Retrospective study. Setting A tertiary referral center.
Eduardo S. Farinazzo, Rubens V. de Brito Neto, Elisabete H. Yamaguti, Marco A. Fornazieri, Luiz F. M. Lourençone   +4 more
wiley   +1 more source