Results 61 to 70 of about 13,799 (205)

Clinical aspects of hearing loss associated with cisplatin therapy – a review [PDF]

Romanian Journal of Military Medicine, 2014
Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity.
Felician Chirteş
doaj  

Sulfasalazine Enhances Copper Toxicity in Danio rerio Larvae: Divergent Protective Roles of Deferoxamine and Ferrostatin‐1

Environmental Toxicology, EarlyView.
ABSTRACT Copper is an environmental contaminant capable of disrupting redox homeostasis and impairing antioxidant defenses in aquatic organisms, thereby increasing susceptibility to oxidative stress. The cystine/glutamate antiporter (system xc−) plays a central role in maintaining intracellular glutathione (GSH) levels, a major antioxidant defense ...
Maria Vitória Takemura Mariano, Pedro Henrique Vicenzi, Vitor Oliveira de Rosso, Mauro Eugênio Medina Nunes, Layla da Silva Braga, Analía Del Valle Garnero, Ricardo José Gunski, Marcelo Farina, Thaís Posser, Jeferson Luis Franco   +9 more
wiley   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

The Role of Anatomy‐Based Fitting in Bimodal Rehabilitation: Choosing Electrode Arrays Based on Cochlear Length

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives To evaluate the clinical impact of anatomy‐based fitting (ABF) in cochlear implants for patients with asymmetric hearing loss. Study Design Prospective cohort study. Setting Tertiary referral center specializing in hearing disorders.
Andrea Canale, Arianna Daquino, Maria Gragnano, Claudia Filippini, Marco Boldreghini, Giuseppe Riva, Andrea Albera   +6 more
wiley   +1 more source

Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells

Current Research in Toxicology
Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity.
Shomaila Mehmood, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel   +3 more
doaj   +1 more source

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong, Joseph Joseph, Deborah Poh, Orli Wargon, Artiene Tatian   +4 more
wiley   +1 more source

Impact of Treatment Intensity on Quality of Life in Patients With Metastatic Testicular Cancer

Andrology, EarlyView.
ABSTRACT Introduction Testicular cancer (TC) is the most common malignancy in young men and is highly curable with platinum‐based chemotherapy. With growing survivorship rates, treatment‐related symptom burden and quality of life (QoL) have become increasingly important.
Pailin Pongratanakul, Tamim Hadjizada, Sophia Thy, Marieke Vermeulen‐Spohn, Günter Niegisch, Peter Albers, Yue Che   +6 more
wiley   +1 more source

The efficacy of strategies used to minimise or prevent Cisplatin-induced ototoxicity in patients

South African Journal of Oncology, 2019
Background: Hearing loss is a major side effect of cisplatin-based chemotherapy. With a large burden of cancer in developing countries, an evidence-based approach to prevention of cisplatin-induced hearing loss (ototoxicity) is pertinent.
Zenzo S. Chakara, Lebogang Ramma
doaj   +1 more source

Modifiable Risk Factors and Hearing Loss: The National Health and Nutrition Examination Survey 1999–2020

Clinical Otolaryngology, EarlyView.
ABSTRACT Objective To explore the associations between major modifiable risk factors and hearing loss. Methods This serial cross‐sectional study was conducted within the National Health and Nutrition Examination Survey 1999–2020 in the United States. Associations were assessed using modified Poisson regression and within‐sample population attributable ...
Yulu Zheng, Tingting Li, Zhiyuan Wu, Yahong Zhu, Zheng Guo, Xingang Li   +5 more
wiley   +1 more source

Efficacy and Mechanisms of Antioxidant Compounds and Combinations Thereof against Cisplatin-Induced Hearing Loss in a Rat Model

Antioxidants
Cisplatin is an election chemotherapeutic agent used for many cancer treatments. Its cytotoxicity against neoplastic cells is mirrored by that taking place in healthy cells and tissues, resulting in serious adverse events.
Liliana Carles, Alejandro Gibaja, Verena Scheper, Juan C. Alvarado, Carlos Almodovar, Thomas Lenarz, José M. Juiz   +6 more
doaj   +1 more source