Results 81 to 90 of about 13,799 (205)

Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta‐analysis

BJU International, Volume 138, Issue 3, Page 370-378, September 2026.
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa, Ali Amiri, Sanchit Kaushal, Emma Wilson, Isabelle Tan, Robert J. Hamilton   +5 more
wiley   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, Volume 13, Issue 16, 18 August 2026.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

A dermatosurgically optimized ear tamponade technique to prevent external auditory canal obstruction – a method for secure closure

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Martin Flatz, Sandra Schreiner, Christian Kunte   +2 more
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation

Frontiers in Immunology
Cisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when high doses are required. Cisplatin-induced ototoxicity
Raheem F. H. Al Aameri, Raheem F. H. Al Aameri, Entkhab M. A. Alanisi, Dheyaa Al Sallami, Ian Alberts, Shelley Tischkau, Leonard P. Rybak, Vickram Ramkumar   +7 more
doaj   +1 more source

Temporal Modulation Enhances Medial Olivocochlear Reflex Efficacy: A TEOAE Suppression Study With Amplitude‐Modulated Broadband Noise

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Introduction The medial olivocochlear reflex (MOCR), an efferent feedback pathway, modulates cochlear gain to enhance signal detection in noise. It is commonly assessed non‐invasively via contralateral suppression of transient‐evoked otoacoustic emissions (TEOAEs). While unmodulated noise is a standard elicitor, ecologically relevant amplitude‐
İrem Sendesen, İrem Karakuluk
wiley   +1 more source

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Purpose Patients unable to receive cisplatin due to age, comorbidities, or reduced performance status are commonly treated with concurrent radiotherapy (RT) and cetuximab. This study evaluated the prognostic significance of the Geriatric 8 (G8) score and the Charlson Comorbidity Index (CCI) in predicting survival outcomes in this population ...
Esin Kiraz, Mete Gündoğ, Rıdvan Gönül, İrfan Kara, İmdat Yüce, Sedat Çağlı   +5 more
wiley   +1 more source

Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels

Frontiers in Molecular Biosciences
This review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels.
Man Yu, Man Yu, Juanjuan Li, Xianhai Zeng, Xianhai Zeng   +4 more
doaj   +1 more source

Audiovestibular Outcomes After Parathyroidectomy in Primary Hyperparathyroidism

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objective To prospectively evaluate audiovestibular outcomes following parathyroidectomy in patients with primary hyperparathyroidism (pHPT) using a comprehensive battery of audiological, vestibular, and patient‐reported outcome measures. Methods This prospective observational study included 31 adult patients undergoing parathyroidectomy for ...
Erdem Köroğlu, Halil Erdem Özel, Seda Erem Basmaz, Melikşah Çakır   +3 more
wiley   +1 more source

Longitudinal Evaluation of Otoacoustic Emissions as a Screening Tool for High‐Frequency Hearing Loss in Adolescents

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 2, Page 480-486, August 2026.
Abstract Objective To investigate the association between distortion product otoacoustic emission (DPOAE) signal‐to‐noise ratios (SNRs) and pure‐tone audiometry (PTA) thresholds in adolescents, both cross‐sectionally at age 18 and longitudinally by evaluating whether DPOAE SNRs at age 13 predict high‐frequency hearing loss (HFHL) at age 18.
Stefanie N. H. Reijers, Angeline E. Meerkerk‐Meijer, Jantien L. Vroegop, Geert Geleijnse, Bernd Kremer, Marc P. van der Schroeff   +5 more
wiley   +1 more source