Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis
Cells, 2019 Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent ...
Mi-Jin Choi +8 more
doaj +1 more source
Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis
BJU International, Volume 138, Issue 1, Page 33-44, July 2026.Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon +3 more
wiley +1 more source
Cisplatin Ototoxicity: Where We Are?
, 2013 Objective: Ototoxicity is a dose limiting side effect of Cisplatin based chemotherapy protocols. Currently there is no approved agent against Cisplatin ototoxicity.
Olgun, YÜKSEL
core
Table4_Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis.XLSX
, 2022 Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Yan Yu (56143) +10 more
core +1 more source
South African Journal of Communication Disorders, 2019 Background: South Africa is a high-burden multi-drug-resistant tuberculosis (MDR-TB) country. Previously, standard MDR-TB treatment regimen in South Africa included kanamycin, an aminoglycoside, which can cause permanent hearing loss in patients.
Lebogang Ramma +2 more
doaj +1 more source
Could edaravone prevent gentamicin ototoxicity? An experimental study
, 2017 Objectives: Clinical application of gentamicin may cause nephrotoxicity and ototoxicity. Our study is the first study to investigate the protective effects of edaravone against the gentamicin-induced ototoxicity.
ONAL, K. +4 more
core +1 more source
Bacterial Ghosts as Innovative Transport Vehicles for Platinum‐Based Anticancer Drugs
ChemMedChem, Volume 21, Issue 12, 26 June 2026.Bacterial ghosts (BGs), empty envelopes of Gram‐negative E. coli, are introduced as versatile carriers for platinum anticancer drugs. Oxaliplatin (OXA) shows high loading, stability, and reproducible encapsulation, while retaining full cytotoxicity in vitro.
Irena Pashkunova‐Martic +9 more
wiley +1 more source
Hearing loss amongst DR-TB patients that have received extended high-frequency pure tone audiometry monitoring (KUDUwave) at three DR-TB decentralized sites in Kwazulu Natal [PDF]
, 2018 Magister Public Health - MPHOtotoxic induced hearing loss is a common adverse event related to aminoglycosides used in Multi Drug Resistant -Tuberculosis treatment. Exposure to ototoxic drugs damages the structures of the inner ear.
Rudolph-Claasen, Zerilda Suzette
core
Prevention of treatment-induced ototoxicity: An update for clinicians
, 2019 Ototoxicity is a common side-effect during treatment of a a number of life-threatening health conditions. Often, when treating such conditions, the focus tends to be on saving the patient’s life rather than preserving their hearing or vestibular function.
Heinze, Birgit +5 more
core +1 more source
Table6_Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis.XLSX
, 2022 Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Yan Yu (56143) +10 more
core +1 more source