Results 111 to 120 of about 17,163 (245)

Risk Factors for Cisplatin-Associated Ototoxicity in Pediatric Oncology Patients

, 2012
Background: Cisplatin is an effective chemotherapy agent against several pediatric malignancies. One of its side effects is irreversible sensorineural hearing damage that is highly variable with a reported incidence of 22-70%.
Renbarger, Jamie, Harris, Michael S., Egbelakin, Akinbode, Yancey, Allison, Pisoni, David B., Gilbert, Jaimie   +5 more
core   +1 more source

Mitigation of Cisplatin‐Induced Neurotoxicity via Nrf2/HO‐1 Signaling and Autophagy: The Protective Role of Vitamin D

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study investigates the neuroprotective effect of vitamin D against cisplatin‐induced mitochondrial damage and oxidative stress (ROS). HO‐1 expression is increased by vitamin D, which triggers Nrf2 activation and nuclear translocation. The results demonstrate that vitamin D protects brain tissue by strengthening the antioxidant defense system ...
Songul Cuglan, Azibe Yildiz, Kevser Tanbek   +2 more
wiley   +1 more source

Ototoxic drugs, diagnosis and monitoring

, 2019
Ototoxicity is a cochlear or vestibular dysfunction caused by chemical, physical or biological effects. It affects the internal ear and hearing nerve and might be reversible or irreversible.
Tan M., Toplu Y.
core  

The Incidence of Ototoxicity in Patients Using Iron Chelators

, 2017
Karakus, Volkan/0000-0001-9178-2850; uzay cetinkaya, petek/0000-0002-0236-8330; Azik, Fatih/0000-0001-5715-4244WOS: 000402429700026PubMed ID: 27879229OBJECTIVE: In this study, we aimed to detect the incidences of ototoxicity in patients with ...
Volkan Karakus, Fatih Mehmet Azik, Azik, Fatih Mehmet, Yasar Topal, Topal, Yasar, Cetinkaya, Petek Uzay, Topal, Hatice, Tansel Erdem Azik, Serhan Derin, Petek Uzay Cetinkaya, Murat Sahan, Karakus, Volkan, Can Naci Kocabas, Derin, Serhan, Kocabaş, Can Naci, Hatice Topal   +15 more
core   +1 more source

Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss?

The Laryngoscope, Volume 136, Issue 6, Page 2708-2718, June 2026.
Sudden sensorineural hearing loss is traditionally treated with steroids, either orally and/or via intratympanic injections, and hyperbaric oxygen treatment (HBOT) has resurged in popularity as an adjunctive therapy. The study has not found any additional treatment benefit with adjunctive concurrent HBOT; however, HBOT might be of value to patients ...
Jennifer L. Spiegel, Michael J. De Biasio, Gianluca Sampieri, Omer J. Ungar, Munir D. Bajin, Vincent Y. W. Lin, Joseph M. Chen, Chris Idestrup, Jordan Tarshis, Trung N. Le   +9 more
wiley   +1 more source

Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels

Frontiers in Molecular Biosciences
This review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels.
Man Yu, Man Yu, Juanjuan Li, Xianhai Zeng, Xianhai Zeng   +4 more
doaj   +1 more source

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

The Laryngoscope, Volume 136, Issue 6, Page 2449-2460, June 2026.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian, Inabat Yermesheva, Ostap Orishchak, Hady Tall, Sam J. Daniel   +4 more
wiley   +1 more source

Mechanisms of clinical ototoxicity and inner ear protection

, 2017
Clinical ototoxicityâpermanent hearing loss caused by medicationsâis estimated to affect millions of patients annually. Two classes of drug are largely to blame: platinum-based chemotherapeutics, primarily cisplatin, and aminoglycoside antibiotics ...
Andrew Breglio, Breglio, Andrew
core   +1 more source

Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation

Frontiers in Immunology
Cisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when high doses are required. Cisplatin-induced ototoxicity
Raheem F. H. Al Aameri, Raheem F. H. Al Aameri, Entkhab M. A. Alanisi, Dheyaa Al Sallami, Ian Alberts, Shelley Tischkau, Leonard P. Rybak, Vickram Ramkumar   +7 more
doaj   +1 more source

Efficacy of a Quantitative Intra‐Operative Facial Nerve Continuous Monitoring System for Functional Preservation Following Intratemporal Facial Nerve Schwannoma Resection

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
We investigated the role of a continuous, quantitative intraoperative monitoring system in surgeries for facial nerve schwannomas, a rare tumor associated with a high risk of facial nerve dysfunction. By continuously stimulating the facial nerve and recording electromyographic responses in real time, the system enabled surgeons to detect subtle or ...
Makoto Hosoya, Marie N. Shimanuki, Masafumi Ueno, Satoshi Suda, Takeshi Wakabayashi, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi   +7 more
wiley   +1 more source