Results 131 to 140 of about 17,163 (245)

Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis

Scientific Reports
Nobiletin, a citrus polymethoxy flavonoid with antiapoptotic and antioxidative properties, could safeguard against cisplatin-induced nephrotoxicity and neurotoxicity.
Wenao Song, Li Zhang, Xiaolin Cui, Rongrong Wang, Jingyu Ma, Yue Xu, Yan Jin, Dawei Wang, Zhiming Lu   +8 more
doaj   +1 more source

Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy

The FEBS Journal, Volume 293, Issue 12, Page 3461-3465, June 2026.
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck, Lukas David Landegger   +1 more
wiley   +1 more source

Study of streptomycin‑induced ototoxicity: protocol for a longitudinal study

, 2016
Hearing impairment is due to various causes including ototoxicity from aminoglycosides. The susceptibility to aminoglycosides increases in the presence of certain mitochondria gene mutations.
Oluwatosin, O., Omotade, O. O., Adeyemo, A. A.   +2 more
core  

A review: Pharmaceutical induced ototoxicity

Ototoxicity, defined as drug-induced damage to the auditory and vestibular systems, manifests as hearing loss, tinnitus, dizziness, and balance disorders, representing a critical challenge in clinical practice and pharmaceutical development.
Oltulu, Cagatay, Dasman, Mustafa
core   +1 more source

Ototoxicity: a high risk to auditory function that needs to be monitored in drug development

Frontiers in Molecular Neuroscience
Hearing loss constitutes a major global health concern impacting approximately 1.5 billion people worldwide. Its incidence is undergoing a substantial surge with some projecting that by 2050, a quarter of the global population will experience varying ...
Marie-Pierre Pasdelou, Lise Byelyayeva, Susanna Malmström, Sylvie Pucheu, Marie Peytavy, Hugo Laullier, Donald B. Hodges, Abraham R. Tzafriri, Gaëlle Naert   +8 more
doaj   +1 more source

Properties of maximum length sequence and nonlinear volterra slice otoacoustic emissions

, 2008
Evoked otoacoustic emissions (EOAEs) are produced by the cochlea and provide anobjective and non-invasive measure of cochlear function. A new technique, based onMaximum Length Sequences (MLSs) enables stimulus rates of up to 5000 clicks/s to beused, and ...
Ismail-Koch, Hasnaa
core  

Cisplatin ototoxicity.

Practica Oto-Rhino-Laryngologica, 1985
Morita, Ichiro, Hosokawa, Satoru, Hiraide, Fumihisa, Inouye, Tetsuzo   +3 more
openaire   +2 more sources

Pharmacology and Ototoxicity

Seminars in Hearing, 2019
openaire   +3 more sources

Issue Information

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
No abstract is available for this article.
wiley   +1 more source

Audiologic Assessment and Management of Teprotumumab-Associated Ototoxicity: An Updated Narrative Review. [PDF]

Audiol Res
Williams J, Elkins A, Sarigul A, Johnson MF, Bishop CE.   +4 more
europepmc   +1 more source