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Journal of Infectious Diseases, 1969
gentamicin treatment. The majority of these patients were known already at the time of the first gentamicin symposium [2-5]. Of these patients, 8 had hearing disturbances of varying degree, 10 had complete loss of vestibular function, 1 had slight vestibular disturbance, and 6 had doubtful vestibular disorders that were reversible.
J, Wersäll +2 more
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gentamicin treatment. The majority of these patients were known already at the time of the first gentamicin symposium [2-5]. Of these patients, 8 had hearing disturbances of varying degree, 10 had complete loss of vestibular function, 1 had slight vestibular disturbance, and 6 had doubtful vestibular disorders that were reversible.
J, Wersäll +2 more
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Acta Oto-Laryngologica, 1982
Ototoxicity and efficacy of netilmicin was evaluated in 76 consecutive patients with moderate to severe infections with Gram-negative rods and Staphylococcus aureus. Netilmicin alone was efficacious in 47 patients and in another 23 patients cure or improvement was seen with netilmicin combined with another antibiotic, usually penicillin.
O, Tjernström +4 more
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Ototoxicity and efficacy of netilmicin was evaluated in 76 consecutive patients with moderate to severe infections with Gram-negative rods and Staphylococcus aureus. Netilmicin alone was efficacious in 47 patients and in another 23 patients cure or improvement was seen with netilmicin combined with another antibiotic, usually penicillin.
O, Tjernström +4 more
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Veterinary Clinics of North America: Small Animal Practice, 1994
This article describes the pathophysiology of ototoxic agents and contains a list of potential ototoxic agents including a list of animal species in which the toxicity has been documented or research studies performed.
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This article describes the pathophysiology of ototoxic agents and contains a list of potential ototoxic agents including a list of animal species in which the toxicity has been documented or research studies performed.
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Otolaryngology–Head and Neck Surgery, 1989
Neither otomycoses nor defects of the tympanic membrane are rare. In cases of fungal infection when the tympanic membrane is not intact, the possibility exists that antimycotic medication could enter the middle ear and diffuse into the cochlea via the round window.
R R, Marsh, L W, Tom
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Neither otomycoses nor defects of the tympanic membrane are rare. In cases of fungal infection when the tympanic membrane is not intact, the possibility exists that antimycotic medication could enter the middle ear and diffuse into the cochlea via the round window.
R R, Marsh, L W, Tom
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American Journal of Otolaryngology, 1986
The author participated in two prospective studies of patients receiving aminoglycoside antibiotics. In the first study, 54 patients received amikacin, and 54 received gentamicin. In the second study, 61 patients received gentamicin, 50 received netilmicin, and 52 received tobramycin.
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The author participated in two prospective studies of patients receiving aminoglycoside antibiotics. In the first study, 54 patients received amikacin, and 54 received gentamicin. In the second study, 61 patients received gentamicin, 50 received netilmicin, and 52 received tobramycin.
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Current Opinion in Otolaryngology & Head & Neck Surgery, 2007
To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
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To summarize mechanisms of ototoxicity associated with aminoglycoside antibiotics and discuss possible protective strategies.Studies in the past 15 years have demonstrated that aminoglycoside ototoxicity is mediated by an apoptotic form of cell death which employs caspase-dependent pathways. Reactive oxygen species have been demonstrated in the sensory
Mark Douglas, Rizzi, Keiko, Hirose
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Otolaryngologic Clinics of North America, 1993
The aminoglycoside antibiotics are active bactericidal agents used for the treatment of tuberculosis and gram-negative bacterial infections. Well over 2 million patients per year receive aminoglycosides; however, a major limitation to their use is ototoxicity (cochleotoxicity and vestibulotoxicity), nephrotoxicity, and neuromuscular blockade ...
C M, Henley, L P, Rybak
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The aminoglycoside antibiotics are active bactericidal agents used for the treatment of tuberculosis and gram-negative bacterial infections. Well over 2 million patients per year receive aminoglycosides; however, a major limitation to their use is ototoxicity (cochleotoxicity and vestibulotoxicity), nephrotoxicity, and neuromuscular blockade ...
C M, Henley, L P, Rybak
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American Journal of Otolaryngology, 1980
Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Aminoglycoside antibiotics are frequently employed in the treatment of serious infections caused by aerobic gram negative bacilli. The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. Impaired renal
S A, Lerner, G J, Matz
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Archives of Otolaryngology - Head and Neck Surgery, 1968
CHLOROQUINE PHOSPHATE is a valuable drug used in the control of malaria and the treatment of amebiasis. The drug was developed in the United States during World War II for use as an antimalarial agent because of the shortage of quinine; the drug had been synthesized and studied as early as 1934 in Germany.
G J, Matz, R F, Naunton
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CHLOROQUINE PHOSPHATE is a valuable drug used in the control of malaria and the treatment of amebiasis. The drug was developed in the United States during World War II for use as an antimalarial agent because of the shortage of quinine; the drug had been synthesized and studied as early as 1934 in Germany.
G J, Matz, R F, Naunton
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Drugs of Today, 2003
Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
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Over the last 10 years new information has been published providing a better understanding of the risk factors, mechanism and prevention of aminoglycoside ototoxicity. The use of a higher dose and once-daily intravenous administration of aminoglycosides has shown clinical effectiveness with no increase in ototoxicity when compared to traditional ...
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