Results 101 to 110 of about 25,486 (236)

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam, Md. Zahid Hasan, Md. Touki Tahamid Tusar, Md. Yeamin Hossain, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Jubaer‐Al‐Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian, Hafizur Rahman Gazi, B. M. Mahmudul Hasan, Md. Shofiul Azam, Md. Enamul Haque, Abdullah‐Al‐Jubayer, Md. Faruk Hasan, F. M. Ali Haydar, Md. Khalekuzzaman, Md. Torequl Islam, Sohel Hasan   +19 more
wiley   +1 more source

Suppression of the TGF-β signaling exacerbates degeneration of auditory neurons in kanamycin-induced ototoxicity in mice

Scientific Reports
Transforming growth factor-β (TGF-β) signaling plays a significant role in multiple biological processes, including inflammation, immunity, and cell death. However, its specific impact on the cochlea remains unclear.
Yoshihiro Nitta, Takaomi Kurioka, Sachiyo Mogi, Hajime Sano, Taku Yamashita   +4 more
doaj   +1 more source

Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis

Cells, 2019
Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent ...
Mi-Jin Choi, Hyunsook Kang, Yun Yeong Lee, Oak-Sung Choo, Jeong Hun Jang, Sung-Hee Park, Jong-Seok Moon, Seong Jun Choi, Yun-Hoon Choung   +8 more
doaj   +1 more source

Rate of Hearing Loss in Platinum‐Naïve Patients Receiving Immune Checkpoint Inhibitors

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1289-1297, May 2026.
Abstract Objective Hearing loss from immune checkpoint inhibitors (ICIs) has been documented in case reports and case series. We present the largest retrospective study investigating the rate of ICI‐related ototoxicity in a monitored cohort of platinum‐naïve patients. Study Design Retrospective cohort study. Setting Tertiary‐care center.
Kaitlyn A. Brooks, Christopher G. Gidley, Olivia Grimley, Catherine Wang, Shirin Jivani, Dianna Roberts, Aung Naing, Jack Phan, Katherine Hutcheson, Xin Wang, Paul W. Gidley, Marc‐Elie Nader   +11 more
wiley   +1 more source

Statistical factors associated with utilisation of ototoxicity monitoring services for multi-drug-resistant tuberculosis patients in the Western Cape

South African Journal of Communication Disorders, 2019
Background: South Africa is a high-burden multi-drug-resistant tuberculosis (MDR-TB) country. Previously, standard MDR-TB treatment regimen in South Africa included kanamycin, an aminoglycoside, which can cause permanent hearing loss in patients.
Lebogang Ramma, Primrose T. Nhokwara, Christine Rogers   +2 more
doaj   +1 more source

Migraine Features in Patients With Sudden Sensorineural Hearing Loss

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1263-1269, May 2026.
Abstract Objective To investigate the prevalence of migraine features among patients with sudden sensorineural hearing loss (SSNHL) and evaluate potential clinical associations. Study Design Retrospective survey‐based study. Setting Single institution tertiary care center. Methods 168 adult patients with SSNHL were recruited.
Yalda Yazdani, Ella J. Lee, Amanda Francis, Saharnaz Nedjat, Mehdi Abouzari, Hamid R. Djalilian   +5 more
wiley   +1 more source

Protecting mammalian hair cells from aminoglycoside-toxicity: assessing phenoxybenzamine’s potential [PDF]

, 2017
Aminoglycosides (AGs) are widely used antibiotics because of their low cost and high efficacy against gram-negative bacterial infection. However, AGs are ototoxic,causing the death of sensory hair cells in the inner ear. Strategies aimed at developing or
Guy P. Richardson, Jonathan E. Gale, Jonathan E. Gale, Paromita Majumder, Paulette A. Moore   +4 more
core   +2 more sources

Chorioamnionitis treatment for women with isolated intrapartum fever: A cost‐effectiveness analysis

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Objective Intrapartum fever (≥38°C) occurs in many laboring patients annually in the United States, but whether an isolated fever should be treated as chorioamnionitis remains controversial. Antibiotic treatment may help reduce the impact of infection as compared to expectant management but may lead to other complications and increase costs ...
Prakrunya Subhasree Badrinarayan, Megha Arora, Aaron B. Caughey   +2 more
wiley   +1 more source

Vancomycin toxicity in neonates: a review of the evidence. [PDF]

, 2016
PURPOSE OF REVIEW: Vancomycin is a first-line agent in the treatment of serious Gram-positive infections in the neonatal population. The published evidence on vancomycin toxicity in neonates is limited.
Heath, PT, Hill, LF, Lestner, JM, Sharland, M   +3 more
core   +1 more source

Clinical Predictors of Cisplatin Chemoradiation-Induced Ototoxicity in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study

Journal of Otolaryngology - Head and Neck Surgery
Background Cisplatin-based chemoradiation is a standard treatment for many patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), an etiologically distinct subset of head and neck cancer. Although associated with
John JW. Lee MD, Salahaldin Alamleh BHSc, Luna Jia Zhan MPH, Katrina Hueniken MSc, Mary B. Mahler MD, Astrid Billfalk-Kelly MD, Joel Davies MD, M. Catherine Brown MSc, Anna Spreafico MD, Shao Hui Huang MSc, Andrew Hope MD, Wei Xu PhD, David P. Goldstein MD, Geoffrey Liu MD   +13 more
doaj   +1 more source