Results 71 to 80 of about 17,163 (245)

Protective Effects of Glucose-Related Protein 78 and 94 on Cisplatin-Mediated Ototoxicity

Antioxidants, 2020
Cisplatin is a widely used chemotherapeutic drug for treating various solid tumors. Ototoxicity is a major dose-limiting side effect of cisplatin, which causes progressive and irreversible sensorineural hearing loss.
Junyeong Yi, Tae Su Kim, Jhang Ho Pak, Jong Woo Chung   +3 more
doaj   +1 more source

Secondary leukaemia after testicular germ cell tumour treatment: a systematic review and meta‐analysis

BJU International, EarlyView.
Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–35 years. Management options for men with TGCTs include surgery, radiation and/or chemotherapy, depending on stage. Given TGCTs’ excellent survival, most patients live long enough to experience delayed treatment toxicities, warranting careful consideration of ...
Ahmad Mousa, Ali Amiri, Sanchit Kaushal, Emma Wilson, Isabelle Tan, Robert J. Hamilton   +5 more
wiley   +1 more source

Bromocriptine-associated ototoxicity

, 1984
Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Morgan, MY, Ballantyne, J, Lanthier, PL
core  

N-Acetyl Cysteine Reduces Cisplatin Ototoxicity

, 2016
Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ...
Yazıcı, Cevat, Mehmet Akif Somdas, Esra Balcioglu, Güntürk, Inayet, Balcıoğlu, Esra, Somdaş, Mehmet Akif, Yazici, Cevat, Gunduz, Mehmet, Mehmet Gunduz, Cevat Yazici, Balcioglu, Esra, Avci, Deniz, Unsal, Selim, Inayet Gunturk, Selim Unsal, Deniz Avci   +15 more
core   +1 more source

An Ototoxicity Grading System Within a Mobile App (OtoCalc) for a Resource-Limited Setting to Guide Grading and Management of Drug-Induced Hearing Loss in Patients With Drug-Resistant Tuberculosis: Prospective, Cross-Sectional Case Series

JMIR mHealth and uHealth, 2020
BackgroundTuberculosis (TB) affects millions of people worldwide and is treated with medication including aminoglycosides and polypeptides. Individuals respond differently to medications as a result of their genetic inheritance.
Hollander, Cara, Joubert, Karin, Schellack, Natalie   +2 more
doaj   +1 more source

Clinical and Social Determinants of Treatment Adherence in Cancer Patients: The Contributory Role of Hearing Loss. [PDF]

Laryngoscope Investig Otolaryngol
ABSTRACT Purpose Treatment adherence is a key determinant of outcomes in cancer patients and is influenced by multiple clinical and social factors. Hearing loss (HL) may contribute to communication barriers and treatment disruption. This study aimed to evaluate the relationship between HL and treatment adherence.
Kılıçtaş B, Kılıçtaş AU, Erdem RÖ, Oruç A, Araz M, Eryılmaz MK, Kocak MZ, Arbağ H, Artaç M.   +8 more
europepmc   +2 more sources

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells

Current Research in Toxicology
Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity.
Shomaila Mehmood, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel   +3 more
doaj   +1 more source

Clinical aspects of hearing loss associated with cisplatin therapy – a review [PDF]

Romanian Journal of Military Medicine, 2014
Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity.
Felician Chirteş
doaj  

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source