Results 71 to 80 of about 25,486 (236)
DPOAE in HIV infected adults [PDF]
, 2008 HIV infection is associated with impairment of hearing function, at any stage of disease causing complication to the external, middle, inner ear and CNS.
Bhat, Jayashree S, Ranjan, Rajesh
core
Protective Effects of Glucose-Related Protein 78 and 94 on Cisplatin-Mediated Ototoxicity
Antioxidants, 2020 Cisplatin is a widely used chemotherapeutic drug for treating various solid tumors. Ototoxicity is a major dose-limiting side effect of cisplatin, which causes progressive and irreversible sensorineural hearing loss.
Junyeong Yi +3 more
doaj +1 more source
Ménière's Disease: A Tri‐Decade Scoping Review of Treatment Trends and Evidence Quality
The Laryngoscope, EarlyView.This tri‐decade scoping review of Ménière's disease literature reveals a significant increase in high‐level evidence and a clinical pivot toward hearing‐preserving interventions, such as intratympanic steroids and cochlear implants. However, a significant quality paradox has emerged, where adherence to standardized AAO‐HNS reporting and diagnostic ...
Ofir Zavdy +4 more
wiley +1 more source
Clinical Issues Surrounding Once-Daily Aminoglycoside Dosing in Children [PDF]
, 2003 Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8–12 hours.
Buss, William F. +2 more
core +2 more sources
ToxicsOtotoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the ...
Gregory M. Zarus +6 more
doaj +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions
Sensory Neuroscience, EarlyView.ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang +7 more
wiley +1 more source
Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats [PDF]
, 2015 Aquest article conté una errata annexadaOtotoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported during washout after chronic ototoxicity, although
Boadas i Vaello, Pere +3 more
core +1 more source
Current Research in ToxicologyOtotoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity.
Shomaila Mehmood +3 more
doaj +1 more source
Clinical aspects of hearing loss associated with cisplatin therapy – a review [PDF]
Romanian Journal of Military Medicine, 2014 Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity.
Felician Chirteş
doaj