Results 71 to 80 of about 19,052 (152)

Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells

Current Research in Toxicology
Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity.
Shomaila Mehmood, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel   +3 more
doaj   +1 more source

Systemic ototoxicity: a review

, 2006
Background: Systemic ototoxicity is a significant cause of vestibulocochlear morbidity in sub-Saharan Africa. It may result in permanent hearing impairment and/or balance problems.Objectives: To review the literature pertaining to the ototoxic potential ...
Shine, NP, NP Shine, Coates, H, H Coates
core   +1 more source

Table7_Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis.XLSX

, 2022
Aminoglycoside antibiotics are widely used for the treatment of serious acute infections, life-threatening sepsis, and tuberculosis, but all aminoglycosides cause side effects, especially irreversible ototoxicity.
Yan Yu (56143), Chen Zhang (66790), Jieyu Qi (7105475), Yuguang Niu (11387679), Yunhao Wu (4604983), Xin Chen (14149), Geping Wu (10183164), Renjie Chai (276884), Qilei Zhang (12433341), Qiaojun Fang (211668), Kaiming Su (491616)   +10 more
core   +1 more source

Pharmacogenetics of drug-induced ototoxicity caused by aminoglycosides and cisplatin

, 2017
Aminoglycosides and the anticancer drug cisplatin can cause permanent hearing loss, which impacts patients’ quality of life and results in considerable subsequent costs.
Claudia Lanvers-Kaminsky, Giuliano Ciarimboli   +1 more
core   +1 more source

A review: Pharmaceutical induced ototoxicity

Ototoxicity, defined as drug-induced damage to the auditory and vestibular systems, manifests as hearing loss, tinnitus, dizziness, and balance disorders, representing a critical challenge in clinical practice and pharmaceutical development.
Oltulu, Cagatay, Dasman, Mustafa
core   +1 more source

Levosimendan ameliorates cisplatin-induced ototoxicity: Rat model

, 2019
Objectives: Cisplatin is employed for chemotherapeutic purposes in several types of adult and pediatric cancer. However, side-effects including nephrotoxicity, ototoxicity, gastrointestinal effects and neuropathy restrict the use of the drug due to their
GÖZELER, Mustafa Sıtkı, AŞKIN, Seda, AKDEMİR, FAZİLE NUR EKİNCİ, YILDIRIM, Serkan, Eser, Gizem, ŞAHİN, Abdulkadir   +5 more
core   +1 more source

Efficacy and Mechanisms of Antioxidant Compounds and Combinations Thereof against Cisplatin-Induced Hearing Loss in a Rat Model

Antioxidants
Cisplatin is an election chemotherapeutic agent used for many cancer treatments. Its cytotoxicity against neoplastic cells is mirrored by that taking place in healthy cells and tissues, resulting in serious adverse events.
Liliana Carles, Alejandro Gibaja, Verena Scheper, Juan C. Alvarado, Carlos Almodovar, Thomas Lenarz, José M. Juiz   +6 more
doaj   +1 more source

The efficacy of strategies used to minimise or prevent Cisplatin-induced ototoxicity in patients

South African Journal of Oncology, 2019
Background: Hearing loss is a major side effect of cisplatin-based chemotherapy. With a large burden of cancer in developing countries, an evidence-based approach to prevention of cisplatin-induced hearing loss (ototoxicity) is pertinent.
Zenzo S. Chakara, Lebogang Ramma
doaj   +1 more source

Effect of Mesenchymal Stem Cells on Cochlear Cell Viability After Cisplatin Induced Ototoxicity

, 2020
Aims: Ototoxicity is one of the main side effects of the chemotherapeutic agent Cisplatin (CDDP). CDDP ototoxicity is caused by damage of the organ of Corti, spiral ganglion cells or lateral wall (stria vascularis and spiral ligament).
Evin Eskicioğlu, Hande, Olgun, Yüksel, Altun, ZEKİYE SULTAN, Guneri, Alpin, Aydin, Melek, Kırkım, Günay, Aktaş, Safiye, Erçetin, Ayşe Pınar, Olgun, Nur, Safiye Aktas, Zekiye Altun, Hande Evin, Alpin Guneri, Melek Aydin, Gunay Kirkim, Yuksel Olgun, Ayse Pinar Ercetin, Nur Olgun   +17 more
core   +1 more source

Suppression of the TGF-β signaling exacerbates degeneration of auditory neurons in kanamycin-induced ototoxicity in mice

Scientific Reports
Transforming growth factor-β (TGF-β) signaling plays a significant role in multiple biological processes, including inflammation, immunity, and cell death. However, its specific impact on the cochlea remains unclear.
Yoshihiro Nitta, Takaomi Kurioka, Sachiyo Mogi, Hajime Sano, Taku Yamashita   +4 more
doaj   +1 more source