Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
, 2019 Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L. +8 more
core +1 more source
Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
, 2019 Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
core +2 more sources
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]
PLoS ONE, 2014 To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke +7 more
doaj +1 more source
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies [PDF]
, 2012 The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound.
Goutman, Juan Diego
core +1 more source
Stereociliary Myosin-1c Receptors Are Sensitive to Calcium Chelation and Absent from Cadherin 23 Mutant Mice [PDF]
, 2006 The identities of some of the constituents of the hair-cell transduction apparatus have been elucidated only recently. The molecular motor myosin-1c (Myo1c) functions in adaptation of the hair-cell response to sustained mechanical stimuli and is ...
Cyr, Janet L +4 more
core +1 more source
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core +1 more source
Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
doaj +1 more source
Keratin-mediated hair growth and its underlying biological mechanism
Communications Biology, 2022 Injecting human hair-derived keratin into mice skin accelerates hair growth & formation, as TGFβ2 secretion during hair destruction stimulates epithelial cell death and keratin release, leading to dermal cell condensation & hair growth.
Seong Yeong An +10 more
doaj +1 more source
Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. [PDF]
, 1997 Myosin VIIA is expressed by sensory hair cells and has a primary structure predicting a role in membrane trafficking and turnover, processes that may underlie the susceptibility of hair cells to aminoglycoside antibiotics. [3H]Gentamicin accumulation and
Brown, S D M +5 more
core +2 more sources
A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
doaj +1 more source