Sensory hair cell death and regeneration in fishes [PDF]
Frontiers in Cellular Neuroscience, 2015 Sensory hair cells are specialized mechanotransductive receptors required for hearing and vestibular function. Loss of hair cells in humans and other mammals is permanent and causes reduced hearing and balance.
Jerry D. Monroe +2 more
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Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model [PDF]
Frontiers in Cellular Neuroscience, 2020 Sensorineural hearing loss is a common disability often caused by the loss of sensory hair cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the development of novel therapeutics for sensorineural hearing loss.
Mami Matsunaga +7 more
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Hair Cell Regeneration: From Animals to Humans [PDF]
Clinical and Experimental OtorhinolaryngologyCochlear hair cells convert sound into electrical signals that are relayed via the spiral ganglion neurons to the central auditory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents.
Sung-Won Choi +2 more
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Suppression of Inflammation Delays Hair Cell Regeneration and Functional Recovery Following Lateral Line Damage in Zebrafish Larvae [PDF]
Biomolecules, 2020 Cochlear hair cells in human beings cannot regenerate after loss; however, those in fish and other lower species can. Recently, the role of inflammation in hair cell regeneration has been attracting the attention of scientists.
Ru Zhang +5 more
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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals [PDF]
eLife, 2022 Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer +15 more
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Single-cell atlas comparison across vertebrates reveals auditory cell evolution and mechanisms for hair cell regeneration [PDF]
Communications BiologyMammals suffer permanent hearing impairment from the loss of auditory hair cells due to their inability to regenerate. In contrast, lower vertebrates exhibit extraordinary capacity for hair cell regeneration and hearing restoration, but the mechanisms ...
Yafan Wang +13 more
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Pharmaceutics, 2023 Sensorineural hearing loss has been a global burden of diseases for decades. However, according to recent progress in experimental studies on hair cell regeneration and protection, clinical trials of pharmacotherapy for sensorineural hearing loss have ...
Mami Matsunaga, Takayuki Nakagawa
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Genes and DiseasesMammalian hair follicles undergo periodic regeneration, with recent research highlighting the immunological niche as a critical regulator of stem cell activity and hair follicle regeneration.
Nana Tao +4 more
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Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration. [PDF]
Dev Cell, 2022 Baek S +6 more
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Frontiers in Cellular Neuroscience, 2021 Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a key regulator of hair cell development and regeneration in the inner
Amrita A. Iyer +4 more
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