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The Genetics of Hair Cell Development and Regeneration [PDF]
Annual Review of Neuroscience, 2013 Sensory hair cells are exquisitely sensitive vertebrate mechanoreceptors that mediate the senses of hearing and balance. Understanding the factors that regulate the development of these cells is important, not only to increase our understanding of ear development and its functional physiology but also to shed light on how these cells may be replaced ...
Andrew K, Groves +2 more
openaire +2 more sources
Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]
, 2015 Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger +25 more
core +1 more source
eLife, 2023 A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi +7 more
doaj +1 more source
Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults.
PLoS ONE, 2012 Sensory hair cells in the zebrafish lateral line regenerate rapidly and completely after damage. Previous studies have used a variety of ototoxins to kill lateral line hair cells to study different phenomena including mechanisms of hair cell death and ...
Scott M Mackenzie, David W Raible
doaj +1 more source
Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium
iScience, 2023 Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga +7 more
doaj +1 more source
Wound Induced Hair Neogenesis – A Novel Paradigm for Studying Regeneration and Aging
Frontiers in Cell and Developmental Biology, 2020 Hair follicles are the signature dermal appendage of mammals. They can be thought of as mini-organs with defined polarity, distinct constituent cell types, dedicated neurovascular supply, and specific stem cell compartments. Strikingly, some mammals show
Myan Bhoopalam +2 more
doaj +1 more source
Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model
Frontiers in Cellular Neuroscience, 2022 Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine.
Xin Deng, Zhengqing Hu, Zhengqing Hu
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, nonmammalian vertebrates are capable of regenerating lost sensory hair cells.
Yingzi eHe +6 more
doaj +1 more source
Brain Sciences, 2020 Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration.
Patricia M. White
doaj +1 more source
Transcriptomic characterization of dying hair cells in the avian cochlea
Cell Reports, 2021 Summary: Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated.
Nesrine Benkafadar +5 more
doaj +1 more source