Results 31 to 40 of about 5,738,873 (283)
Prolonged Dexamethasone Exposure Enhances Zebrafish Lateral-Line Regeneration But Disrupts Mitochondrial Homeostasis and Hair Cell Function [PDF]
, 2022 The synthetic glucocorticoid dexamethasone is commonly used to treat inner ear disorders. Previous work in larval zebrafish has shown that dexamethasone treatment enhances hair cell regeneration, yet dexamethasone has also been shown to inhibit ...
Warchol, Mark E +8 more
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Return of function after hair cell regeneration [PDF]
Hearing Research, 2013 The ultimate goal of hair cell regeneration is to restore functional hearing. Because birds begin perceiving and producing song early in life, they provide a propitious model for studying not only whether regeneration of lost hair cells can return auditory sensitivity but also whether this regenerated periphery can restore complex auditory perception ...
Brenda M, Ryals +2 more
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Development and regeneration of vestibular hair cells in mammals [PDF]
Seminars in Cell & Developmental Biology, 2017 Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small organs in the inner ear. Damage to hair cells and their innervating neurons can cause crippling symptoms such as vertigo, visual field oscillation, and imbalance.
Joseph C, Burns, Jennifer S, Stone
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Cell Reports, 2023 Summary: We explore the changes in chromatin accessibility and transcriptional programs for cochlear hair cell differentiation from postmitotic supporting cells using organoids from postnatal cochlea.
Gurmannat Kalra +13 more
doaj +1 more source
The effect of anti-inflammatory drugs on hair cell regeneration in the zebrafish lateral line [PDF]
, 2014 Hair cell death and regeneration on the three distal-most neuromasts in the posterior lateral line of zebrafish larvae were investigated after neomycin treatment.
Garbo, Sarah C
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Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis
Pharmaceutics, 2022 In the large full-thickness mouse skin regeneration model, wound-induced hair neogenesis (WIHN) occurs in the wound center. This implies a spatial regulation of hair regeneration.
Hans I-Chen Harn +9 more
doaj +1 more source
Cochlear hair cell regeneration based on stem cells: A systematic review [PDF]
According to the World Health Organization (WHO), by 2050 at least 700 million people will need access to hearing care and hearing rehabilitation services.
Clemêncio, Filomena +6 more
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Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish
Cell Regeneration, 2016 Background: We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity negatively impacts hair cell ...
Wuhong Pei +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 The hair cells of the cochlea play a decisive role in the process of hearing damage and recovery, yet knowledge of their regeneration process is still limited.
Jianyong Chen +35 more
doaj +1 more source
Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. [PDF]
, 2015 The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic ...
Mark eEddison +14 more
core +1 more source