Emerging biomedical engineering strategies for hair follicle regeneration [PDF]
Bioactive MaterialsHair follicle undergoes cyclical regeneration that relies on the spatiotemporal coordination of epithelial-mesenchymal interactions and multiple signaling pathways. However, hair follicle homeostasis is susceptible to disruption by various endogenous and
Lijun Cai, Yuan Jin Zhao, Minhui Lu
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An induced pluripotent stem cell-based approach for hair follicle development and regeneration
Regenerative TherapyBecause hair loss is a common concern for many individuals, potential regenerative therapies of hair follicles have been extensively researched. Induced pluripotent stem cells (iPSCs) are a promising avenue for hair follicle regeneration.
Ramya Lakshmi Rajendran +2 more
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Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice [PDF]
CellsHair follicle (HF) stem cells are multipotent adult stem cells that play a key role in the hair follicle cycle. However, it remains poorly understood how the outer root sheath (ORS)—specifically, the stem cells in the bulge region of the hair follicle ...
Hangzhen Zhou +4 more
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Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice [PDF]
Nature Communications, 2021 How hair follicle regeneration arises readily in some species ie. spiny rather than laboratory mice, is unclear. Here, authors compare them, showing an optimal stiffness is needed for placode formation and the difference in hair follicle regenerative ...
Hans I-Chen Harn +17 more
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PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration [PDF]
Stem Cell Research & Therapy, 2020 Background Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair follicle formation are poorly ...
Yu Chen +7 more
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Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration [PDF]
Experimental and Molecular MedicineHair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles.
Jung Hyun Lee, Sekyu Choi
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METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis. [PDF]
PLoS GeneticsRapid hair follicle cycling requires precise fate commitment and differentiation of hair follicle stem cells. While the essential role of transcription factors in establishing cell identity is well recognized, how cells control its protein synthesis to ...
Xinyan Gan +10 more
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Acta Biochimica et Biophysica Sinica, 2023 Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun +7 more
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Design of a biofluid-absorbing bioactive sandwich-structured Zn–Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing [PDF]
Bioactive Materials, 2021 Chengtie Wu, Zhigang Yang, Wenbo Li
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Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration [PDF]
Journal of Cellular and Molecular Medicine, 2020 Guang Yang, Yaojiong Wu, Deqiang Kong
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