MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration
Nature CommunicationsHair follicles cycle through expansion, regression and quiescence. To investigate the role of MCL‑1, a BCL‑2 family protein with anti‑apoptotic and apoptosis‑unrelated functions, we delete Mcl‑1 within the skin epithelium using constitutive and inducible
Hui San Chin +19 more
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TLR2 regulates hair follicle cycle and regeneration via BMP signaling
eLifeThe etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs).
Luyang Xiong +9 more
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Regenerative potential of CD200- subpopulations of hair follicle bulge [PDF]
Frontiers in Cell and Developmental BiologyThe hair follicle bulge is regarded as a reservoir of epithelial stem cells for hair regeneration. Hair follicle bulge cells are generally characterized by CD200 expression.
Ting Sun +14 more
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Lack of evidence for sprouting of Aβ afferents into the superficial laminas of the spinal cord dorsal horn after nerve section [PDF]
, 2003 The central arborizations of large myelinated cutaneous afferents normally extend as far dorsally as the ventral part of lamina II in rat spinal cord. Woolf et al. (1992) reported that after nerve injury some of these afferents sprouted into lamina I and
Todd, A.J. +3 more
core +9 more sources
Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]
, 2015 The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Haslam, Iain S. +16 more
core +5 more sources
VDR is an essential regulator of hair follicle regression through the progression of cell death
Life Science Alliance, 2023 This study investigates the role of VDR in the progression of catagen, and demonstrates that aberrant regression that ectopically prevents cell death impairs hair follicle regeneration, emphasizing the significance of regression in tissue homeostasis ...
Yudai Joko +7 more
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Wound Induced Hair Neogenesis – A Novel Paradigm for Studying Regeneration and Aging
Frontiers in Cell and Developmental Biology, 2020 Hair follicles are the signature dermal appendage of mammals. They can be thought of as mini-organs with defined polarity, distinct constituent cell types, dedicated neurovascular supply, and specific stem cell compartments. Strikingly, some mammals show
Myan Bhoopalam +2 more
doaj +1 more source
Advances in the study of hair follicle mesenchymal stem cells
Pifu-xingbing zhenliaoxue zazhi, 2022 Hair follicle mesenchymal stem cells (HFMSCs) are slow cycling label retaining cells with self-regeneration ability, high proliferative potential, and multi-directional differentiation.
Huijun LAI +4 more
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Basic principles of hair follicle structure, morphogenesis, and regeneration
, 2023 Diseases affecting the hair follicle are common in domestic animals, but despite the importance of an intact skin barrier and a fully functional hair coat, knowledge about the detailed morphological features and the diversity of these complex mini-organs
Welle, Monika M, Monika M. Welle
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Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles [PDF]
PeerJ, 2019 Secreted Frizzled-related Protein 4 (sFRP4) belongs to Wnt inhibitors. Previously, we reported that sFRP4 inhibited the differentiation of melanocyte.
Haiying Guo +4 more
doaj +2 more sources