Results 51 to 60 of about 5,738,873 (283)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea
Stem Cell Reports, 2014 The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound.
Naomi F. Bramhall +4 more
doaj +1 more source
Advances in the study of hair follicle mesenchymal stem cells
Pifu-xingbing zhenliaoxue zazhi, 2022 Hair follicle mesenchymal stem cells (HFMSCs) are slow cycling label retaining cells with self-regeneration ability, high proliferative potential, and multi-directional differentiation.
Huijun LAI +4 more
doaj +1 more source
K15 & Id3 expression in intact and regenerating adult vibrissae rodent hair follicles [PDF]
, 2009 The hair follicle can renew itself through an intrinsic stem cell population and has the ability to undergo hair follicle growth cycle; its regenerative activities under normal and experimental conditions together with a feature of easy access make it an
Chen, Bo
core
Copper may impair hair cell regeneration.
, 2013 (A, B) Wild type larvae were treated at 5 dpf with serial dilutions of neomycin or copper for 30 min. Hair cell regeneration was scored using FM 1-43FX and normalized to controls.
Scott M. Mackenzie (302231) +1 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Advanced Functional Materials, EarlyView.Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez +9 more
wiley +1 more source
Making sense of Wnt signaling – linking hair cell regeneration to development
Frontiers in Cellular Neuroscience, 2015 Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Lina eJansson, Grace eKim, Alan G Cheng
doaj +1 more source
VDR is an essential regulator of hair follicle regression through the progression of cell death
Life Science Alliance, 2023 This study investigates the role of VDR in the progression of catagen, and demonstrates that aberrant regression that ectopically prevents cell death impairs hair follicle regeneration, emphasizing the significance of regression in tissue homeostasis ...
Yudai Joko +7 more
doaj +1 more source
Dermal and epidermal cell functions in the growth and regeneration of hair follicles and other skin appendages [PDF]
, 1998 Epithelial-mesenchymal interactions are central to the development of skin and skin appendages in vertebrates. These interactions continue throughout adult life and underpin the cyclic growth and loss of hair in mammals. While the molecular basis of such
Gharzi, Ahmad
core