Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes [PDF]
eLife, 2023 A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life.
Tuo Shi +7 more
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The Role of Supporting Cell Populations in Satellite Cell Mediated Muscle Repair [PDF]
Cells, 2023 Skeletal muscle has a high capacity to repair and remodel in response to damage, largely through the action of resident muscle stem cells, termed satellite cells.
Amanda L. Johnson +2 more
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Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model [PDF]
Frontiers in Cellular Neuroscience, 2020 Sensorineural hearing loss is a common disability often caused by the loss of sensory hair cells in the cochlea. Hair cell (HCs) regeneration has long been the main target for the development of novel therapeutics for sensorineural hearing loss.
Mami Matsunaga +7 more
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Mitochondrial trafficking and redox/phosphorylation signaling supporting cell migration phenotypes [PDF]
Frontiers in Molecular Biosciences, 2022 Regulation of cell signaling cascades is critical in making sure the response is activated spatially and for a desired duration. Cell signaling cascades are spatially and temporally controlled through local protein phosphorylation events which are ...
Nathaniel Shannon +3 more
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MECOM promotes supporting cell proliferation and differentiation in cochlea [PDF]
Journal of Otology, 2022 Permanent damage to hair cells (HCs) is the leading cause of sensory deafness. Supporting cells (SCs) are essential in the restoration of hearing in mammals because they can proliferate and differentiate to HCs.
Peipei Chen +7 more
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Fadrozole-mediated sex reversal in the embryonic chicken gonad involves a PAX2 positive undifferentiated supporting cell state [PDF]
Frontiers in Cell and Developmental Biology, 2022 Gonadal sex differentiation among vertebrates involves divergent fates of a common group of progenitor cells present in both presumptive ovaries and testes.
Martin A. Estermann, Craig A. Smith
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Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea [PDF]
Frontiers in Molecular Neuroscience, 2020 Hearing loss is a problem that impacts a significant proportion of the adult population. Cochlear hair cell (HC) loss due to loud noise, chemotherapy and aging is the major underlying cause.
Michael Hoa +14 more
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Sucrose targets clathrin-mediated endocytosis kinetics supporting cell elongation in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2022 Sucrose is a central regulator of plant growth and development, coordinating cell division and cell elongation according to the energy status of plants. Sucrose is known to stimulate bulk endocytosis in cultured cells; however, its physiological role has
Claudio Osorio-Navarro +2 more
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AAVâmediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration [PDF]
Advanced ScienceMammalian cochlear hair cells (HCs) are essential for hearing, and damage to HCs results in severe hearing impairment. Damaged HCs can be regenerated by neighboring supporting cells (SCs), thus the functional regeneration of HCs is the main goal for the ...
Liyan Zhang +12 more
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Dual mechanisms of supporting cell regeneration in the neonatal mouse cochlea [PDF]
iScienceSummary: Cochlear supporting cells are glia-like cells critical for development, homeostasis, and regeneration. In the neonatal mouse cochlea, inner phalangeal cells (IPhCs), a supporting cell subtype surrounding inner hair cells, are uniquely ...
Julia M. Abitbol +7 more
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