Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity [PDF]
Frontiers in Neuroscience, 2022 Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxygen species ...
Sofia Waissbluth +3 more
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Kölliker’s organ-supporting cells and cochlear auditory development [PDF]
Frontiers in Molecular Neuroscience, 2022 The Kölliker’s organ is a transient cellular cluster structure in the development of the mammalian cochlea. It gradually degenerates from embryonic columnar cells to cuboidal cells in the internal sulcus at postnatal day 12 (P12)–P14, with the cochlea ...
Jianyong Chen +11 more
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No Protective Effects of Hair Cells or Supporting Cells in Ototoxically Deafened Guinea Pigs upon Administration of BDNF [PDF]
Brain Sciences, 2021 We investigated whether treatment with brain-derived neurotrophic factor (BDNF), which is known to protect spiral ganglion cells (SGCs), could also protect hair cells (HCs) and supporting cells (SCs) in the organ of Corti of a guinea pig model of ...
Annamaria Tisi +5 more
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Stem cells supporting other stem cells [PDF]
Frontiers in Genetics, 2013 Adult stem cell therapies are increasingly prevalent for the treatment of damaged or diseased tissues, but most of the improvements observed to date are attributed to the ability of stem cells to produce paracrine factors that have a trophic effect on ...
Judith eLeatherman
doaj +3 more sources
Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium [PDF]
iScience, 2023 Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga +7 more
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Damage-evoked signals in cochlear neurons and supporting cells [PDF]
Frontiers in NeurologyIn addition to hearing loss, damage to the cochlea can lead to gain of function pathologies such as hyperacusis. It has been proposed that painful hyperacusis, noxacusis, may be carried to the central nervous system by type II cochlear afferents, sparse,
Megan Beers Wood +3 more
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The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the Transdifferentiation of Auditory Supporting Cells into Hair Cells by Regulating the mTOR Pathway [PDF]
CellsIn mammals, hearing loss is irreversible due to the lack of the regenerative capacity of the auditory epithelium. However, stem/progenitor cells in mammalian cochleae may be a therapeutic target for hearing regeneration.
Yeon Ju Kim +6 more
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LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea [PDF]
Frontiers in Molecular Neuroscience, 2021 Sensorineural hearing loss is mainly caused by irreversible damage to sensory hair cells (HCs). A subgroup of supporting cells (SCs) in the cochlea express leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a marker for tissue-resident ...
Natalia Smith-Cortinez +13 more
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DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration. [PDF]
Proc Natl Acad Sci U S A, 2023 Nguyen JD +5 more
europepmc +2 more sources
TRIM71 reactivation enhances the mitotic and hair cell-forming potential of cochlear supporting cells. [PDF]
EMBO Rep, 2023 Li XJ +4 more
europepmc +2 more sources