Results 21 to 30 of about 1,595,147 (255)
Frontiers in Molecular Neuroscience, 2018 Notch inhibition is known to generate supernumerary hair cells (HCs) at the expense of supporting cells (SCs) in the mammalian inner ear. However, inhibition of Notch activity becomes progressively less effective at inducing SC-to-HC conversion in the ...
Wen-wei Luo +16 more
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Frontiers in Cell and Developmental Biology, 2022 Gonadal sex differentiation among vertebrates involves divergent fates of a common group of progenitor cells present in both presumptive ovaries and testes.
Martin A. Estermann, Craig A. Smith
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Frontiers in Cellular Neuroscience, 2014 The function of the enzyme glutamate decarboxylase (GAD) is to convert glutamate in -aminobutyric acid (GABA).GAD exists as two major isoforms, termed GAD65 and GAD67,.that are usually expressed in GABA-containing neurons in the central nervous system ...
Giancarlo eRusso +8 more
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Tracheal remodelling supports stem cells [PDF]
Nature Cell Biology, 2021 The vascular system, plastic and positioned in the vicinity of tissues, is an undervalued regulator of adult stem cells. Two studies now show that the vascular-like Drosophila trachea is reshaped after intestinal damage or tumour formation and that this remodelling is required for compensatory intestinal stem cell proliferation and tumour growth.
Louis Gervais, Allison J. Bardin
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European Journal of Histochemistry, 2017 Kölliker’s organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5’-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To
Jun Liu +3 more
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Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation
Frontiers in Cell and Developmental Biology, 2019 The mouse cochlea contains approximately 15,000 hair cells. Its dimensions and location, and the small number of hair cells, make mechanistic, developmental and cellular replacement studies difficult.
Danielle R. Lenz +12 more
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Plasticity of Supporting Cells in a Stem Cell Factory [PDF]
Immunity, 2010 In this issue of Immunity, Omatsu et al. (2010) provide new information on the CXCL12 abundant reticular (CAR) cells that support hematopoietic stem cells and lymphoid progenitors in bone marrow. CAR cells can convert to adipocytes and osteoblasts, additional cells known to regulate hematopoiesis.
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Frontiers in Cellular NeuroscienceSensorineural hearing loss, affecting over 1.5 billion people worldwide, results largely from irreversible damage to inner ear hair cells—specialized mechanosensory receptor cells that mammals cannot spontaneously regenerate.
Xiaoyi Zhang +6 more
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Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression. [PDF]
PLoS ONE, 2011 Sensory hair cells and supporting cells of the mammalian inner ear are quiescent cells, which do not regenerate. In contrast, non-mammalian supporting cells have the ability to re-enter the cell cycle and produce replacement hair cells.
Heidi Loponen +3 more
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Mesenchymal Stromal Cells as Supportive Cells for Hepatocytes
Molecular Therapy, 2009 Hepatocytes and hematopoietic stem cells (HSCs) appear to share many of the same requirements for their survival, functionality, and proliferation. This may be due to a shared location during fetal development. Moreover, hepatocytes and HSCs are unable to function, or even survive, without stromal cell support.
Gómez-Aristizábal, Alejandro +2 more
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