Results 11 to 20 of about 8,443,769 (248)

Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea. [PDF]

PLoS ONE, 2013
In mammals, auditory hair cells are generated only during embryonic development and loss or damage to hair cells is permanent. However, in non-mammalian vertebrate species, such as birds, neighboring glia-like supporting cells regenerate auditory hair ...
Soumya Korrapati, Isabelle Roux, Elisabeth Glowatzki, Angelika Doetzlhofer   +3 more
doaj   +2 more sources

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]

PLoS ONE, 2014
To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke, Felicia A Gilels, Wei Pan, Diana Pratt, Jianwen Que, Lin Gan, Patricia M White, Amy E Kiernan   +7 more
doaj   +2 more sources

Corrigendum: Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea [PDF]

Frontiers in Molecular Neuroscience, 2021
Michael Hoa, Rafal Olszewski, Xiaoyi Li, Ian Taukulis, Shoujun Gu, Alvin DeTorres, Ivan A. Lopez, Ivan A. Lopez, Fred H. Linthicum, Fred H. Linthicum, Akira Ishiyama, Akira Ishiyama, Daniel Martin, Robert J. Morell, Matthew W. Kelley   +14 more
doaj   +2 more sources

Single-Cell Sequencing Applications in the Inner Ear

Frontiers in Cell and Developmental Biology, 2021
Genomics studies face specific challenges in the inner ear due to the multiple types and limited amounts of inner ear cells that are arranged in a very delicate structure. However, advances in single-cell sequencing (SCS) technology have made it possible
Mingxuan Wu, Mingyu Xia, Wenyan Li, Huawei Li, Huawei Li, Huawei Li, Huawei Li   +6 more
doaj   +1 more source

Correction to “AAV‐Mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration” [PDF]

Advanced Science
Liyan Zhang, Xin Chen, Xinlin Wang, Yinyi Zhou, Yuan Fang, Xingliang Gu, Ziyu Zhang, Qiuhan Sun, Nianci Li, Lei Xu, Fangzhi Tan, Renjie Chai, Jieyu Qi   +12 more
doaj   +2 more sources

Complement activation induces excessive T cell cytotoxicity in severe COVID-19 [PDF]

, 2021
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology.
Mei, H.E., Paclik, D., Thiel, A., Kurth, F., Saliba, A.E., Schneider, M., Eils, R., Aschenbrenner, A.C., Astaburuaga-García, R., Michalick, L., Brumhard, S., Sander, L.E., Georg, P., Demichev, V., Demir, M., Stein, J., Iwert, C., Lehmann, I., Bonaguro, L., Gäbel, C., Nattermann, J., Ralser, M., Petrov, L., Landthaler, M., Thibeault, C., Aulakh, S.K., Gemünd, I., Schulz, A.R., Stricker, S., Röhmel, J., Müller-Redetzky, H., Djudjaj, S., Boor, P., Wesselmann, H., Barone, M., Obermayer, B., Schultze, J.L., Kostevc, T., von Stillfried, S., Wyler, E., Bülow, R.D., Mall, M.A., Uhrig, A., Streitz, M., Kuebler, W.M., Helbig, E.T., Lippert, L.J., Hippenstiel, S., Suttorp, N., Tober-Lau, P., Beule, D., Sawitzki, B., Mülleder, M., Blüthgen, N., Hillus, D., Meisel, C., Dey, H.P., Corman, V.M., Djudjaj, Sonja, Astaburuaga-García, Rosario, Sawitzki, Birgit, Streitz, Mathias, Sander, Leif E., Wesselmann, Hans, Dey, Hannah-Philine, Kuebler, Wolfgang M., Schneider, Maria, Röhmel, Jobst, Bonaguro, Lorenzo, Uhrig, Alexander, Ralser, Markus, Mei, Henrik E., Georg, Philipp, Landthaler, Markus, Tober-Lau, Pinkus, Suttorp, Norbert, Schulz, Axel R., Boor, Peter, Thiel, Andreas, Wyler, Emanuel, Hillus, David, Blüthgen, Nils, Beule, Dieter, Aulakh, Simran Kaur, Stein, Julia, Müller-Redetzky, Holger, Thibeault, Charlotte, Mülleder, Michael, Eils, Roland, Demichev, Vadim, Mall, Marcus A., Lehmann, Irina, Lippert, Lena J., Petrov, Lev, Bülow, Roman D., Demir, Münevver, Kurth, Florian, Hippenstiel, Stefan, Meisel, Christian, Kostevc, Tomislav, Paclik, Daniela, Stricker, Sebastian, Corman, Victor M., Schultze, Joachim L., Helbig, Elisa T., Obermayer, Benedikt, Brumhard, Sophia, Gemünd, Ioanna, Barone, Matthias, Michalick, Laura, von Stillfried, Saskia, Saliba, Antoine-Emmanuel, Gäbel, Christiane, Aschenbrenner, Anna C., Nattermann, Jacob, Iwert, Christina, Elisa T. Helbig, Julia Stein, Axel R. Schulz, Wolfgang M. Kuebler, Irina Lehmann, Leif E. Sander, Markus Landthaler, Nils Blüthgen, Jacob Nattermann, Jobst Röhmel, Alexander Uhrig, Christiane Gäbel, Laura Michalick, Rosario Astaburuaga-García, Maria Schneider, Emanuel Wyler, Holger Müller-Redetzky, Lorenzo Bonaguro, Charlotte Thibeault, Christian Meisel, Lev Petrov, Markus Ralser, Birgit Sawitzki, Norbert Suttorp, Matthias Barone, David Hillus, Sophia Brumhard, Roland Eils, Pinkus Tober-Lau, Stefan Hippenstiel, Philipp Georg, Antoine-Emmanuel Saliba, Christina Iwert, Dieter Beule, Saskia von Stillfried, Victor M. Corman, Tomislav Kostevc, Daniela Paclik, Ioanna Gemünd, Hannah-Philine Dey, Sonja Djudjaj, Michael Mülleder, Andreas Thiel, Marcus A. Mall, Florian Kurth, Sebastian Stricker, Joachim L. Schultze, Anna C. Aschenbrenner, Henrik E. Mei, Münevver Demir, Roman D. Bülow, Lena J. Lippert, Mathias Streitz, Vadim Demichev, Simran Kaur Aulakh, Benedikt Obermayer, Hans Wesselmann, Peter Boor   +173 more
core   +1 more source

Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway

Frontiers in Cellular Neuroscience, 2022
Most cases of acquired hearing loss are due to degeneration and subsequent loss of cochlear hair cells. Whereas mammalian hair cells are not replaced when lost, in zebrafish, they constantly renew and regenerate after injury.
Guanyun Wei, Xu Zhang, Xu Zhang, Chengyun Cai, Jiajing Sheng, Mengting Xu, Cheng Wang, Qiuxiang Gu, Chao Guo, Fangyi Chen, Fangyi Chen, Dong Liu, Fuping Qian   +12 more
doaj   +1 more source

Epithelial–Mesenchymal Transition Participates in the Formation of Vestibular Flat Epithelium

Frontiers in Molecular Neuroscience, 2021
The vestibular sensory epithelium of humans and mice may degenerate into a layer of flat cells, known as flat epithelium (FE), after a severe lesion. However, the pathogenesis of vestibular FE remains unclear.
Lu He, Guo-Peng Wang, Jing-Ying Guo, Zhong-Rui Chen, Ke Liu, Shu-Sheng Gong   +5 more
doaj   +1 more source

ATP and ACh Evoked Calcium Transients in the Neonatal Mouse Cochlear and Vestibular Sensory Epithelia

Frontiers in Neuroscience, 2021
Hair cells in the mammalian inner ear sensory epithelia are surrounded by supporting cells which are essential for function of cochlear and vestibular systems.
Richard D. Rabbitt, Richard D. Rabbitt, Richard D. Rabbitt, Holly A. Holman   +3 more
doaj   +1 more source

Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle

Frontiers in Cellular Neuroscience, 2019
Spontaneous calcium transients are present during early postnatal development in the mouse retina and cochlea, and play an important role in maturation of the sensory organs and neural circuits in the central nervous system (CNS). It is not known whether
Holly A. Holman, Lauren A. Poppi, Lauren A. Poppi, Micah Frerck, Richard D. Rabbitt, Richard D. Rabbitt, Richard D. Rabbitt   +6 more
doaj   +1 more source