Results 21 to 30 of about 8,443,769 (248)

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

Frontiers in Cellular Neuroscience, 2019
The mechanism underlying hair cell (HC) regeneration in the mammalian inner ear is still under debate. Understanding what molecules regulate the HC regeneration in mature mammals will be the key to the treatment of the inner ear disorder. Musashi1 (MSI1)
Makoto Kinoshita, Chisato Fujimoto, Shinichi Iwasaki, Akinori Kashio, Yayoi S. Kikkawa, Kenji Kondo, Hideyuki Okano, Tatsuya Yamasoba   +7 more
doaj   +1 more source

Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. [PDF]

, 2015
The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic ...
Mark eEddison, Weber, SJ, Ariza-McNaughton, L, Julian eLewis, Nicolas eDaudet, Lewis, J, Sara Johanna Weber, Eddison, M, Daudet, N, Linda eAriza-McNaughton, Sara J. Weber, Mark Eddison, Linda Ariza-McNaughton, Julian Lewis, Nicolas Daudet   +14 more
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Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival

Frontiers in Cellular Neuroscience, 2017
The sensory hair cells of the inner ear are exquisitely sensitive to ototoxic insults. Loss of hair cells after exposure to ototoxic agents causes hearing loss. Chemotherapeutic agents such as cisplatin causes hair cell loss.
Azadeh Jadali, Azadeh Jadali, Azadeh Jadali, Yu-Lan M. Ying, Kelvin Y. Kwan, Kelvin Y. Kwan   +5 more
doaj   +1 more source

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea

Frontiers in Cellular Neuroscience, 2019
Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of ...
Xi Gu, Xi Gu, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai, Luo Guo, Luo Guo, Biao Dong, Wenyan Li, Yilai Shu, Yilai Shu, Xinsheng Huang, Huawei Li, Huawei Li, Huawei Li, Huawei Li, Huawei Li   +17 more
doaj   +1 more source

Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium

Frontiers in Cellular Neuroscience, 2020
Sensory epithelia of the inner ear contain mechanosensory hair cells (HCs) and glia-like supporting cells (SCs), both of which are required for hearing and balance functions.
Erica Sadler, Matthew M. Ryals, Matthew M. Ryals, Lindsey A. May, Daniel Martin, Daniel Martin, Nora Welsh, Erich T. Boger, Robert J. Morell, Ronna Hertzano, Ronna Hertzano, Ronna Hertzano, Lisa L. Cunningham   +12 more
doaj   +1 more source

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease [PDF]

, 2020
Huntington disease (HD) is an inherited late-onset neurological disorder characterized by progressive neuronal loss and disruption of cortical and basal ganglia circuits.
Buffo, Annalisa, Parmar M., Cernigoj M., Parmar, Malin,, Belloli S., Bocchi V. D., Vercelli, Alessandro, Conforti, Paola, Talpo F., Schellino R., Besusso, Dario, Faedo, Andrea,, Belloli, Sara, Vercelli A., Cattaneo E., Spaiardi, Paolo,, Besusso, Dario,, Boido, Marina, Moresco, Rosa Maria,, Vercelli, Alessandro,, Talpo, Francesca,, Parmar, Malin, Laporta, Angela, Laporta, Angela,, Maniezzi, Claudia, Campus, Ilaria,, Spaiardi, Paolo, Maniezzi C., Toselli M. G., Belloli, Sara,, Lund University., Faedo, Andrea, Campus I., Maniezzi, Claudia,, Buffo, Annalisa,, Parolisi R., Faedo A., Spaiardi P., Cernigoj, Manuel, Murtaj, Valentina,, Schellino, Roberta, Moresco, Rosa Maria, Cattaneo, Elena, Parolisi, Roberta, Biella, Gerardo, Boido M., Murtaj V., Campus, Ilaria, Conforti P., Cattaneo, Elena,, Laporta A., Schellino, Roberta,, Bocchi, Vittoria Dickinson, Bocchi, Vittoria Dickinson,, Bocchi V, Toselli, Mauro Giuseppe, Toselli, Mauro Giuseppe,, Besusso D., Buffo A., Parolisi, Roberta,, Moresco R. M., Biella, Gerardo,, Biella G., Conforti, Paola,, Talpo, Francesca, Boido, Marina,, Murtaj, Valentina, Cernigoj, Manuel,, Dario Besusso, Francesca Talpo, Mauro Giuseppe Toselli, Angela Laporta, Roberta Schellino, Roberta Parolisi, Marina Boido, Andrea Faedo, Annalisa Buffo, Alessandro Vercelli, Sara Belloli, Paola Conforti, Valentina Murtaj, Claudia Maniezzi, Gerardo Biella, Vittoria Dickinson Bocchi, Elena Cattaneo, Manuel Cernigoj, Ilaria Campus, Rosa Maria Moresco, Malin Parmar Paolo Spaiardi   +88 more
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Green preparation of self-supporting platinum nanoflower catalyst and its electrocatalytic oxidation performance of methanol

Carbon Resources Conversion, 2023
The three-dimensional (3D) self-supporting Pt nanoflower catalyst was prepared by using Pt organic compounds as precursors in a low-temperature molten salt system.
Zhen Lu, Hongjie Kang, Ji Li, Jianpeng Shang, Kun Yang, Rui Liu, Zuopeng Li, Feng Feng, Yong Guo, Haidong Zhao   +9 more
doaj   +1 more source

Haematopoietic stem cell transplantation: activity in Switzerland compared with surrounding European countries [PDF]

, 2013
Haematopoietic stem cell transplantation (HSCT) is a highly specialised procedure used to treat malignancies of the lymphohaematopoietic system as well as some acquired and inherited disorders of the blood.
Gratwohl, A, Bargetzi, Mario, Stussi, Georg, Renner, Christoph, Güngör, T, Bucher, Christoph, Chalandon, Yves, Ozsahin, Hulya, Leibundgut, Kurt, Gratwohl, Alois, Schanz, Urs, Leibundgut, K, Stussi, G, Ozsahin, Ayse Hulya, Baldomero, H, Pabst, T, Chalandon, Y, Schanz, U, Passweg, Jakob R, Ozsahin, H, Passweg, Jakob, Pabst, Thomas, Passweg, J R, Hess, U, Renner, C, Duchosal, M A, SBST (Swiss Blood Stem Cell Transplantation Group),, Bargetzi, M, Duchosal, Michel A, Stern, Martin, de Faveri, Grazia Nicoloso, Güngör, Tayfun, de Faveri, G N, Bucher, C, Baldomero, Helen, Hess, Urs, Stern, M, Bargetzi, M., Passweg, J.R., Bucher, C., Leibundgut, K., Renner C, Duchosal, M.A., Stern, M., Hess U, Renner, C., Güngör T, Schanz, U., Gratwohl A, Passweg JR, Bargetzi M, Chalandon, Y., Gratwohl, A., Stern M, Bucher C, Ozsahin H, Baldomero, H., de Faveri, G.N., de Faveri GN, Baldomero H, Ozsahin, H., Pabst T, Güngör, T., Stussi G, Schanz U, Pabst, T., Stussi, G., Duchosal MA, Hess, U., Chalandon Y, Leibundgut K   +70 more
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CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC- Expressing Macrophages [PDF]

, 2018
Hematopoiesis is regulated by crosstalk between long-term repopulating hematopoietic stem cells (LT-HSCs) and supporting niche cells in the bone marrow (BM). Here, we examine the role of CD82/ KAI1 in niche-mediated LT-HSC maintenance. We found that CD82/
Sang Eun Lee, Jin Hur, Ji-Yeon Yun, Jae-Il Choi, Kyungjin Boo, Tae-Won Kim, Pniel Nham, Sung Hee Baek, Jeehoon Kang, ROH, TAE YOUNG, Cheong-Whan Chae, Hwan Lee, Chang-Hwan Yoon, Hyo-Soo Kim, Jong Kwan Jun, Jin-A Kang, Ho Lee, Seokjin Ham   +17 more
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Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury [PDF]

, 2012
Transplantation of MSC into the acute injured spinal cord is sufficient to enhance oligodendroglial differentiation of endogenous spinal cord progenitor cells up to one month post-injury.
Bründl, Johannes
core   +1 more source