Results 71 to 80 of about 1,367,224 (352)

Assessment of drug permeability through an ex vivo porcine round window membrane model

iScience, 2023
Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear.
Adele Moatti, Dylan Silkstone, Taylor Martin, Keith Abbey, Kendall A Hutson, Douglas C Fitzpatrick, Carlton J Zdanski, Alan G Cheng, Frances S Ligler, Alon Greenbaum   +9 more
doaj   +1 more source

Miniature Soft Robot With Magnetically Reprogrammable Surgical Functions

Advanced Materials, EarlyView.
Miniature soft robots have great prospects to revolutionize minimally invasive treatments. Here we present a miniature soft robot, which can be reprogrammed to perform five surgical functionalities with six‐degrees‐of‐freedom motions. This soft robot can prospectively make minimally invasive surgery considerably safer and painless, and enable ...
Chelsea Shan Xian Ng, Yu Xuan Yeoh, Nicholas Yong Wei Foo, Keerthana Radhakrishnan, Guo Zhan Lum   +4 more
wiley   +1 more source

Flexibility within the middle ears of vertebrates [PDF]

, 2013
Introduction and aims: Tympanic middle ears have evolved multiple times independently among vertebrates, and share common features. We review flexibility within tympanic middle ears and consider its physiological and clinical implications.
Mason, Matthew J., Farr, Matthew R. B., M R B Farr, M J Mason   +3 more
core   +1 more source

Application of Nanomedicine in Inner Ear Diseases

Frontiers in Bioengineering and Biotechnology, 2022
The treatment of inner ear disorders always remains a challenge for researchers. The presence of various physiological barriers, primarily the blood–labyrinth barrier (BLB), limits the accessibility of the inner ear and hinders the efficacy of various ...
Qianyu Lin, Qianyu Lin, Qiong Guo, Qiong Guo, Mingchao Zhu, Juanli Zhang, Bei Chen, Tingting Wu, Tingting Wu, Wei Jiang, Wei Jiang, Wenxue Tang, Wenxue Tang   +12 more
doaj   +1 more source

Classification and Current Management of Inner Ear Malformations

Balkan Medical Journal, 2017
Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells.
L. Sennaroğlu, Münir Demir Bajin
semanticscholar   +1 more source

Intrinsically Stretchable Piezoelectric Nanocomposites for Artificial Ultrasonic Sensory Synapse

Advanced Materials, EarlyView.
Applying ultrasonic stimulations to a soft‐stretchable underwater piezoelectric sensor based on the soft‐stretchable nanocomposite from the thermal cross‐linking between the ─C─F group of P(VDF‐TrFE) and the ─NH2 group of (PEG‐diamine) with incorporating amine‐terminated BTO@APTES nanofillers on the soft PDMS substrates generated high piezoelectric ...
Trung Dieu Do, Tran Quang Trung, Priyanuj Bhuyan, Minh Chien Nguyen, Que Thi Nguyen, Namjun Jo, Yeonsu Kim, Thanh Duy Cam Ha, Myung‐Gil Kim, Sungjune Park, Woo Jong Yu, Nae‐Eung Lee   +11 more
wiley   +1 more source

Introduction of Transmembrane Inner Ear (tmie) Gene Can Recover the Hearing Impairment and Abnormal Behavior in the Circling Mouse [PDF]

, 2008
The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing the causative gene, transmembrane inner ear (tmie), for the phenotypic rescue of the circling mouse.
Mi Jung Shin, Myoung Ok Kim, Byung-Hwa Hyun, Bong Soo Kim, Raekil Park, Sung Hyun Kim, Jun-Gyo Suh, Jeong-Han Lee, Zae Young Ryoo, Dong Hoon Yu, Hei Jung Kim, Channy Park, Hong-Seob So, Sanggyu Lee   +13 more
core   +1 more source

NOX3-Targeted Therapies for Inner Ear Pathologies [PDF]

, 2015
Inner ear pathologies are associated with major morbidity and loss of life quality in affected patients. In many of these conditions, production of reactive oxygen-species (ROS) is thought to be a key pathological mechanism.
Senn, Pascal, Krause, Karl-Heinz, Rousset, Francis, Carnesecchi, Stephanie   +3 more
core   +1 more source

Diagnosis and Management of Autoimmune Inner Ear Disease

Jurnal Otorinolaringologi Kepala dan Leher Indonesia
Latar Belakang: Autoimmune Inner Ear Disease adalah penyakit autoimun gangguan pendengaran sensorineural, dengan angka kejadian kurang dari 1% dari di seluruh dunia.
Muhammad Arifudin, Rossy Rosalinda
doaj   +1 more source

Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture.

PLoS ONE, 2016
Stem cell-derived inner ear sensory epithelia are a promising source of tissues for treating patients with hearing loss and dizziness. We recently demonstrated how to generate inner ear sensory epithelia, designated as inner ear organoids, from mouse ...
Rachel E DeJonge, Xiao-Ping Liu, Christopher R Deig, Stefan Heller, Karl R Koehler, Eri Hashino   +5 more
doaj   +1 more source