Results 81 to 90 of about 119 (119)

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source

Clinical Effectiveness of Sialendoscopy in Radioactive Iodine‐induced Sialadenitis: A Systematic Review and Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To systematically review and synthesize outcomes following sialendoscopy in patients with salivary gland dysfunction and a history of radioactive iodine (RAI). Data Sources A comprehensive search of Medline, Embase, and Cochrane Library was conducted from database inception through December 26, 2025.
Michal Kulasek, Alexander C. Moise, Sam J. Daniel   +2 more
wiley   +1 more source

Improving Voice Outcomes After Transoral Laser Surgery for Early Glottic Cancer: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To determine which intraoperative and postoperative interventions improve voice outcomes following transoral laser microsurgery (TLM) for early‐stage glottic squamous cell carcinoma (T1‐T2). Data Sources English literature was searched on PubMed, OVID Medline, CINAHL, Embase, and Scopus. Review Methods PRISMA guidelines were followed.
Jamie T. Koscak, Kalpesh Hathi, Melina E. Markotjohn, Adrian I. Mendez, Jonathan R. Trites, Matthew H. Rigby, S. Mark Taylor, Timothy F. E. Brown, Ayham Al Afif   +8 more
wiley   +1 more source

Influence of Vitamin B12 Deficiency on Auditory and Vestibular Functioning: An Objective Test‐Based Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the effectiveness of objective audiological and vestibular assessments in detecting functional changes associated with vitamin B12 deficiency. Data Sources A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and EMBASE databases.
Nesmah Zainab, Santhosh Periyasamy, Kishan Madikeri Mohan   +2 more
wiley   +1 more source

Applications and prospects of artificial intelligence and digital medicine in pediatric nasal skull base tumors

Pediatric Investigation, EarlyView.
Pediatric nasal skull base tumors present diagnostic and therapeutic challenges due to their deep location, nonspecific symptoms, and the narrow nasal cavity in children. Although artificial intelligence (AI) and digital medicine have advanced early diagnosis, multidisciplinary treatment, and prognosis, their application in these rare tumors remains ...
Xiuping Wu, Jing Wei, Chen Liu, Pengpeng Wang, Wentong Ge, Yang Han   +5 more
wiley   +1 more source

Rhyming in the cold: first evidence of soniferous fishes in the Southern Ocean

Remote Sensing in Ecology and Conservation, EarlyView.
The acoustic ecology of Southern Ocean fishes remains unknown due to a lack of dedicated acoustic research on the fishes of this ocean. Passive acoustic monitoring data were collected at the South African sub‐Antarctic Prince Edward Islands using an underwater acoustic recorder, and towed underwater Ski‐Monkey cameras were deployed to identify fish ...
Fannie W. Shabangu, Grant van der Heever, Charles von der Meden, Hannah Truter, Stephen J. Lamberth, Ofer Gon   +5 more
wiley   +1 more source

Interrelationships Among Stakeholder‐Perceived Factors Influencing Solar PV Adoption in Passive Houses in New Zealand

Sustainable Development, EarlyView.
ABSTRACT The adoption of solar photovoltaic systems (SPVS) in passive houses (PHs) is shaped by technical, economic and policy‐related factors. Yet, the interactions among these factors have not been quantitatively modelled in the New Zealand context.
Franklin Chukwuebuka Nkado, Itohan Esther Aigwi, Dat Tien Doan, Ali GhaffarianHoseini   +3 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source