Results 81 to 90 of about 1,367,224 (352)
Advanced Materials Interfaces, EarlyView.Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley +1 more source
Identification and characterisation of gene regulation by the POU4F3 (BRN-3C) transcription factor in the inner ear [PDF]
, 2010 Hair cells are the mechanosensory cells of the inner ear whose loss causes irreversible hearing loss in mammals. POU4F3, a POU-domain transcription factor, is only expressed in hair cells in the inner ear and is essential for hair cell terminal ...
Tornari, C.
core
Biomaterial-based drug delivery systems in the treatment of inner ear disorders
Journal of NanobiotechnologyInner ear disorders are among the predominant etiology of hearing loss. The blood-labyrinth barrier limits the ability of drugs to attain pharmacologically effective concentrations within the inner ear; consequently, delivering drugs systemically is ...
Hong Cheng +10 more
doaj +1 more source
EARLY STEPS IN INNER EAR DEVELOPMENT: INDUCTION AND MORPHOGENESIS OF THE OTIC PLACODE
Frontiers in Pharmacology, 2015 Various cellular replacement therapies using in vitro generated cells to replace damaged tissue have been proposed as strategies to alleviate hearing loss.
Xaiorei eSai, Raj K. Ladher
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Advanced Materials Technologies, EarlyView.A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo +4 more
wiley +1 more source
AKT signaling mediates IGF-I survival actions on otic neural progenitors [PDF]
, 2012 Background: Otic neurons and sensory cells derive from common progenitors whose transition into mature cells requires the coordination of cell survival, proliferation and differentiation programmes.
Sanchez-Calderon, Hortensia +19 more
core +1 more source
Frontiers in PharmacologyIntroduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear.
Adele Moatti +18 more
doaj +1 more source
Hearing Research, 2018 Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug and application protocol in humans largely empirically‐derived.
A. Salt, S. Plontke
semanticscholar +1 more source
Fabrication of Fibers With Complex Features Using Thermal Drawing of 3D‐Printed Preforms
Advanced Materials Technologies, EarlyView.3D printing enables rapid fabrication of macroscale polymer preforms with complex geometries. Thermal drawing then scales these structures into long fibers while preserving micron‐scale cross‐sectional features. This workflow provides a fast, low‐cost route to functional fibers with tailored geometries and material combinations for catheter, robotic ...
Ali Anil Demircali +4 more
wiley +1 more source
Advanced Robotics Research, EarlyView.This work presents a state‐adaptive Koopman linear quadratic regulator framework for real‐time manipulation of a deformable swab tool in robotic environmental sampling. By combining Koopman linearization, tactile sensing, and centroid‐based force regulation, the system maintains stable contact forces and high coverage across flat and inclined surfaces.
Siavash Mahmoudi +2 more
wiley +1 more source