Results 91 to 100 of about 96,350 (311)

Progenitor Cells from the Adult Human Inner Ear. [PDF]

, 2019
Loss of inner ear hair cells leads to incurable balance and hearing disorders because these sensory cells do not effectively regenerate in humans. A potential starting point for therapy would be the stimulation of quiescent progenitor cells within the ...
Stefan Volkenstein, Veronika Kranebitter, Volkenstein, Stefan, Kranebitter, Veronika, Oshima, Kazuo, Amir Mina, Mina, Amir, Senn, Pascal, Stefan Heller, Pascal Senn, Heller, Stefan, Kazuo Oshima   +11 more
core   +1 more source

Statistical shape modeling of the human inner ear through micro‐computed tomography imaging

The Anatomical Record, EarlyView.
In this study, 54 cadaveric temporal bone specimens underwent high‐resolution micro‐CT imaging. Images were semi‐automatically segmented and converted to 3D surface mesh models for morphological measurement and analysis. Statistical shape models were created for the inner ear, cochlea, and vestibular system, as well as for sex‐ and side‐based subgroups.
Carmine Spedaliere, Alexandra Vaupotic, Jaehyun Hwang, Khalil Husein, Mustafa Hafidh, Kyle Rioux, S. Alireza Rohani, Sumit K. Agrawal, Hanif M. Ladak   +8 more
wiley   +1 more source

AKT signaling mediates IGF-I survival actions on otic neural progenitors

, 2012
Background: Otic neurons and sensory cells derive from common progenitors whose transition into mature cells requires the coordination of cell survival, proliferation and differentiation programmes.
Sanchez-Calderon, Hortensia, Marta Magariños, Leon, Yolanda, Maria R Aburto, Maria R. Aburto (186884), Varela-Nieto, Isabel, Yolanda Leon (5649538), Leon Yolanda, Yolanda Leon, Rodriguez Aburto, Maria, Magariños Marta, Hortensia Sanchez-Calderon, Hortensia Sanchez-Calderon (186893), Isabel Varela-Nieto (186892), Marta Magariños (186888), Aburto Maria R., Isabel Varela-Nieto, Varela-Nieto Isabel, Sanchez-Calderon Hortensia, Magariños, Marta   +19 more
core   +1 more source

Ontogeny of murine bony semicircular canal form

The Anatomical Record, EarlyView.
Abstract The labyrinthine geometry and functional anatomy of the semicircular canals have intrigued scientists for decades, and there has been considerable interest in understanding how these complex structures grow and develop with evidence emerging from human studies that size maturation occurs exceptionally early by comparison with other systems ...
Marcela Cárdenas‐Serna, Nathan Jeffery   +1 more
wiley   +1 more source

3D anatomical atlas of the heads of male and female adult Chamaeleo calyptratus

The Anatomical Record, EarlyView.
The veiled chameleon is a model organism in reptile development research. Utilizing contrast‐enhanced microCT and deep learning segmentation models, we have generated the first digital atlases of the skull, nervous system, cranial muscles and hyolingual muscles.
Alice Leavey, Eloy Gálvez‐López, Anthony Herrel, Laura B. Porro   +3 more
wiley   +1 more source

Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors

Nature Communications, 2018
Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human ...
Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller, Pascal Senn   +5 more
doaj   +1 more source

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson   +8 more
doaj   +1 more source

Balance function after cochlear implant and inner ear anomaly: Comparison of dynamic posturography

Laryngoscope Investigative Otolaryngology, 2020
Introduction Patients with sensorineural hearing loss suffer concomitant vestibular dysfunction that is more prevalent in patients with inner ear anomaly and could be aggravated with cochlear implantation. To assess the vestibular dysfunction in patients
Farideh Hosseinzadeh, Alimohamad Asghari, Maziar Moradi‐Lakeh, Mohammad Farhadi, Ahmad Daneshi, Mohammad Mohseni, S.Saeed Mohammadi   +6 more
doaj   +1 more source

Inner-Ear Disorders Presenting with Air–Bone Gaps: A Review

, 2020
Air–bone gaps (ABGs) are commonly found in patients with conductive or mixed hearing loss generally due to outer- and/or middle-ear diseases such as otitis externa, tympanic membrane perforation, interruption or fixation of the ossicular chain, and ...
Cavaliere, Matteo, CASSANDRO, Ettore, Matteo Cavaliere, Arianna Di Stadio, cassandro, claudia, Stadio, Arianna Di, Marco de Vincentiis, Di Stadio, Arianna, Gioacchini, Federico Maria, Ettore Cassandro, Troisi, Donato, Antonio Greco, Massimo Ralli, Scarpa, Alfonso, greco, antonio, Federico Maria Gioacchini, Claudia Cassandro, Ralli, Massimo, Alfonso Scarpa, de Vincentiis, marco, Donato Troisi   +20 more
core   +1 more source

New craniodental materials of Falcarius utahensis (Theropoda: Therizinosauria) reveal patterns of intraspecific variation and cranial evolution in early coelurosaurians

The Anatomical Record, EarlyView.
Abstract Despite documented ecomorphological shifts toward an herbivorous diet in several coelurosaurian lineages, the evolutionary tempo and mode of these changes remain poorly understood, hampered by sparse cranial materials for early representatives of major clades. This is particularly true for Therizinosauria, with representative crania best known
William J. Freimuth, Lindsay E. Zanno
wiley   +1 more source