Results 111 to 120 of about 1,367,224 (352)

Middle ear application of a sodium hyaluronate gel loaded with neomycin in a Guinea pig model [PDF]

, 2009
OBJECTIVE: Establishing methods for topical administration of drugs to the inner ear have great clinical relevance and potential even in a relatively short perspective.
Laurell, G,, Laurell, Göran,, Edsman, Katarina, Engmer, C, Saber, Amanj, Edsman, Katarina,, Edsman, K, Saber, Amanj,, Ulfendahl, M,, Ulfendahl, Mats, Bramer, Tobias, Saber, A,, Bramer, Tobias,, Engmér, Cecilia,, Bramer, T, Engmér, Cecilia, Ulfendahl, Mats,   +16 more
core   +3 more sources

Anatomical basis of drug delivery to the inner ear

Hearing Research, 2018
The isolated anatomical position and blood‐labyrinth barrier hampers systemic drug delivery to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round‐ and oval window are established methods for local pharmaceutical ...
R. Glueckert, L. J. Chacko, H. Rask-Andersen, Wei Liu, S. Handschuh, A. Schrott-Fischer   +5 more
semanticscholar   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Flow Phenomena in the Inner Ear [PDF]

, 2019
A remarkable number of different flow phenomena contribute critically to the proper functioning of the hearing and balance senses, both of which are hosted by the inner ear.
Obrist, Dominik
core   +1 more source

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner

Frontiers in Cellular Neuroscience, 2020
Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming.
Marta Magariños, Marta Magariños, Marta Magariños, Raquel Barajas-Azpeleta, Raquel Barajas-Azpeleta, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto, Maria R. Aburto, Maria R. Aburto   +9 more
doaj   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Functional and Morphological characterization of NOD-SCID inner ear [PDF]

, 2013
OBJECTIVE. Sensorineural hearing impairment is a consequence of hair cells (HC) and/or spiral ganglion neurons loss. In mammals, HCs are unable to regenerate, so their loss cause irreversible damages.
ASTOLFI, LAURA, V. Guaran, F. Valente, OLIVETTO, ELENA, MARTINI, ALESSANDRO, P. Giordano, SIMONI, EDI   +6 more
core  

Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish

Biomedicines
Background: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu   +14 more
doaj   +1 more source

The inner ear proteome of fish

The FEBS Journal, 2018
The mechanisms that underpin the formation, growth and composition of otoliths, the biomineralized stones in the inner ear of fish, are largely unknown, as only a few fish inner ear proteins have been reported. Using a partial transcriptome for the inner
Oliver R. B. Thomas, S. Swearer, Eugene A. Kapp, Po Peng, G. Tonkin-Hill, A. Papenfuss, A. Roberts, P. Bernard, Blaine R. Roberts   +8 more
semanticscholar   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source