Results 71 to 80 of about 3,677 (204)

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng, Jieyu Qi, Chen‐Chi Wu, Yilai Shu, Renjie Chai   +4 more
wiley   +1 more source

Endolymphatic sac tumor

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
DOI: 10.3969/j.issn.1672-6731.2019.02 ...
Xiao-ling YAN
doaj  

Unusual endolymphatic sac tumor: case report and literature review

The Egyptian Journal of Otolaryngology
Background Endolymphatic sac tumors (ELSTs) are uncommon low-grade tumors with highly local aggressive features. These tumors could be associated with Von Hippel-Lindau disease or isolated.
Tawfiq Khurayzi, Faisal Hakami, Hassan Ghafiry, Amir Gazali, Sameeh Al-Gassmi, Meshal Jarebi, Ali Kamili   +6 more
doaj   +1 more source

Bilateral Enlarged Vestibular Aqueduct: Auditory, Genetic and Radiological Characterization, and Benefits of Cochlear Implants

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1215-1227, November 2025.
Abstract Objective The study aimed to describe the auditory phenotype of patients with bilateral enlarged vestibular aqueduct, including benefits of cochlear implantation, and to look for genotype‐phenotype correlation. Study Design Retrospective single‐center study. Setting Tertiary adult reference center.
Augustin Vigouroux, Benjamin Glemain, Renato Torres, Laurence Jonard, Natalie Loundon, Evelyne Ferrary, Isabelle Mosnier, Hannah Daoudi, Sandrine Marlin, Ghizlene Lahlou   +9 more
wiley   +1 more source

Microsurgical Outcomes in 1000 Patients With Cerebellopontine Angle Tumors: A Comprehensive Cohort Analysis

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1236-1244, November 2025.
Abstract Objective To summarize the outcomes of 1000 consecutive microsurgical resection of cerebellopontine angle tumors. Study Design Retrospective cohort study. Setting Single tertiary care institution. Methods We analyzed 1000 patients who underwent microsurgical resection of cerebellopontine angle tumors between November 2017 and August 2024 ...
Joshua Lee, Michael G. Brandel, Benjamin T. Ostrander, Philipp Verpukhovskiy, Alena Pauley, Abhishek Bhatt, Alexandra Vacaru, Douglas M. Bennion, Marc S. Schwartz, Rick Friedman   +9 more
wiley   +1 more source

Differences in endolymphatic sac mitochondria-rich cells indicate specific functions.

, 2002
Item does not contain fulltextOBJECTIVE/HYPOTHESIS: The purpose of the study was to examine the specific involvement of endolymphatic sac mitochondria-rich cells in endolymph homeostasis.
Tonnaer, E.L.G.M., Curfs, J.H.A.J., Peters, T.A., Cremers, C.W.R.J., Kuijpers, W.   +4 more
core   +1 more source

Perilymphatic and endolymphatic pressure in the guinea pig after distal dissection of the endolymphatic sac

, 2001
Hypothesis: The study was designed to investigate whether endolymphatic pressure exceeds perilymphatic pressure in an endolymphatic hydrops model with a partially functioning endolymphatic sac.
Wit, HP; id_orcid, Albers, FWJ, Schroder, FHHJ, Warmerdam, TJ, Wit, HP   +4 more
core   +1 more source

Blood Labyrinth Barrier Waste Clearance as Assessed by GBCAs on MRI: A Scoping Review

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 5, October 2025.
ABSTRACT Objective The discovery of the glymphatic system in the brain and eye has raised the hypothesis of a similar system in the inner ear. Dysfunctional lymph fluid dynamics may contribute to inner ear conditions such as Meniere's Disease (MD) and endolymphatic hydrops (EH).
Syed Ameen Ahmad, Emily Y. Huang, Joon Soo Kim, Yassine Balhi, Marcus Spann, Bryan K. Ward   +5 more
wiley   +1 more source

Limited Utility of Existing Hearing Loss Panels in the Assessment of Early‐Onset, Bilateral Meniere's Disease

OTO Open, Volume 9, Issue 4, October-December 2025.
Abstract Objective While the etiology of Meniere's disease (MD) is likely multifactorial, genetics are thought to play a role. Several previous studies have yielded inconclusive results, potentially due to phenotypic uncertainty and variable diagnostic criteria.
Keshav V. Shah, Christian Jung, Daniel Talian, Sherrie Davis, Douglas J. Epstein, Michael J. Ruckenstein, Tiffany P. Hwa   +6 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source