Results 81 to 90 of about 394,098 (286)

Study of Immunohistochemical Expression Patterns of Mismatch Repair Proteins in Endometrial Carcinoma and Endometrial Hyperplasia: An Institutional Study

Indian Journal of Medical and Paediatric Oncology
Introduction Endometrial carcinoma (EC) is the most common cancer in women (7% of all malignancies) standing fourth in prevalence. Its molecular categorization has lately gained substantial importance, because of its prognostic implications ...
Belani Vaishali Tulsidas, Kausalya Kumari Sahu, Ranjitha Rao, Sharada Rai, Chaithra G.V, Cheryl Sarah Philipose   +5 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Water Vapor Endometrial Ablation for Heavy Menstrual Bleeding: 36-Month Follow-Up of a Prospective, Multicenter Pivotal Clinical Trial

International Journal of Women's Health, 2021
Nicholas Leyland,1 Micah Harris2 1Department of Obstetrics and Gynaecology, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, L8S 4K1, Canada; 2AEGEA Medical, Menlo Park, CA, 94025, USACorrespondence: Micah Harris Tel +1 602-828 ...
Leyland N, Harris M
doaj  

The Relationship of Endometrial Pathologies with Endometrial Thickness and Inflammatory Markers in Breast Cancers Using Tamoxifen [PDF]

, 2022
Esma Sarioglu, Fisun Vural, Ayşe Deniz Ertürk Coşkun   +2 more
openalex   +1 more source

The effects of androgen therapy on the endometrium of transgender men [PDF]

, 2017
Individuals who identify themselves as transgender have gender identities that do not match their anatomical sex. Females who identify as male, also known as female-to-male transgender (FTM), may opt to undergo hormonal and surgical treatment in order to
Shah, Anita
core  

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors [PDF]

, 2018
Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant.
Codacci-Pisanelli, G, Del Pup, L, Levi-Setti, P E, Patrizio, P, Peccatori, F A   +4 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

A Case Report of Abdominal Wall Endometriosis with Manifestation of Abdominal and Back Pain

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Endometriosis is defined as the presence of endometrial glands and stroma somewhere outside the uterus. The most common site of involvement is the small intestine and colon, and gastric wall involvement is rare. In this study, a
N Nasirian, H Parsa
doaj  

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source