Posttranslational Modifications of p62/SQSTM1 in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang +8 more
wiley +1 more source
Liquid biopsy as a new era in endometrial cancer
Endometrial cancer (EC) is one of the most frequent invasive cancers of the female genital tract, and despite the rising incidence of EC worldwide and the poor overall survival of patients, no viable blood-based biomarker exists to detect and track EC ...
Zhuri, Drenushe, Yalcintepe, Sinem
core +1 more source
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer
MedComm, Volume 7, Issue 10, October 2026.Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta +2 more
wiley +1 more source
Pipelle Endometrial Biopsy for Abnormal Uterine Bleeding in Daily Clinical Practice: Why the Approach to Patients Should Be Personalized? [PDF]
J Pers Med, 2021 Tanko NM +9 more
europepmc +1 more source
Targeting the DNA Damage Response in Cancer
MedComm, Volume 7, Issue 10, October 2026.Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao +4 more
wiley +1 more source
Pipelle endometrial biopsy for abnormal uterine bleeding: do patient's pain and anxiety really impact on sampling success rate? [PDF]
BMC Womens Health, 2021 Kaiyrlykyzy A +9 more
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Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
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Abortion—A brief description of the evolution of methods
Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1898-1903, October 2026.Termination of pregnancy is not a “modern” societal issue, but one that has been afforded to women, albeit with varying degrees of success, over many centuries. Methods have evolved which have increased the availability, effectiveness, and safety of abortion, while substantially reducing associated morbidity.
Laura Slade, Andrea Deussen, Jodie Dodd
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BIOPSIA ENDOMETRIAL AMBULATORIA: EXPERIENCIA PRELIMINAR
Revista Chilena de Obstetricia y Ginecología, 2006 Objetivo: Presentar la experiencia inicial en el diagnóstico histológico con biopsia endometrial ambulatoria obtenida con pipelle de Cornier. Material y método: Se efectuó biopsia endometrial ambulatoria con pipelle de Cornier en 144 pacientes con ...
Claudio Domínguez C +3 more
doaj
IIB or not IIB, part 2: assessing inter-rater and intra-rater repeatability of the Kenney-Doig scale in equine endometrial biopsy evaluation. [PDF]
J Vet Diagn Invest, 2022 Westendorf J, Wobeser B, Epp T.
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