Results 81 to 90 of about 934,404 (297)

PIK3CA mutations in advanced cancers: characteristics and outcomes. [PDF]

, 2012
PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics.
Falchook, Gerald S, Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S, Janku, Filip, Kurzrock, Razelle, Lee, Jack J, Luthra, Rajyalakshmi, Moulder, Stacy L, Naing, Aung, Piha-Paul, Sarina A, Stepanek, Vanda M, Tsimberidou, Apostolia M, Wheler, Jennifer J   +13 more
core   +4 more sources

Extracellular Vesicles-Based Biomarkers Represent a Promising Liquid Biopsy in Endometrial Cancer

Cancers, 2019
Tumor-derived extracellular vesicles (EVs) are secreted in large amounts into biological fluids of cancer patients. The analysis of EVs cargoes has been associated with patient´s outcome and response to therapy.
C. Herrero, A. de la Fuente, Carlos Casas-Arozamena, V. Sebastián, Martín Prieto, M. Arruebo, A. Abalo, E. Colás, G. Moreno-Bueno, A. Gil-Moreno, A. Vilar, J. Cueva, M. Abal, L. Muinelo-Romay   +13 more
semanticscholar   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

Developmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki, Rinna Kanai, Sayuri Tatsuta, Shinichi Kawaguchi, Masatsune Itoh, Shinsuke Ohba, Makoto Abe   +6 more
wiley   +1 more source

A Structured Assessment to Decrease the Amount of Inconclusive Endometrial Biopsies in Women with Postmenopausal Bleeding [PDF]

, 2016
Objective. To determine whether structured assessment of outpatient endometrial biopsies decreases the number of inconclusive samples. Design. Retrospective cohort study. Setting. Single hospital pathology laboratory. Population.
Breijer, M.C., Doorn, H.C. (Lena) van, Mol, B.W.J. (Ben), Opmeer, B.C. (Brent), Pijnenborg, J.M.A. (Johanna), Timmermans, A. (Anne), Van Der Wurff, A.A.M. (A. A M), Van Hanegem, N., Visser, N.C.M.   +8 more
core   +1 more source

Metastatic Cutaneous Adnexal Carcinoma of the Head and Neck With Durable Response to an Aromatase Inhibitor Combined With a Cyclin‐Dependent Kinase 4/6 Inhibitor

Head &Neck, EarlyView.
ABSTRACT Background Cutaneous adnexal carcinomas are a very rare group of cancers arising from appendageal structures of the skin. More than half occur in the head and neck region. No standard treatments exist for metastatic disease. Methods A 48‐year‐old postmenopausal female presented with an enlarging scalp lesion.
Nilesh Kapoor, Manasa Narasimman, Travis Vandergriff, Amy L. Jones   +3 more
wiley   +1 more source

Diagnostic performance of sonohysterography and MRI diffusion in benign endometrial lesion characterization

The Egyptian Journal of Radiology and Nuclear Medicine, 2018
Objectives: To assess pretreatment endometrial abnormalities in newly diagnosed, nontreated histologically documented breast cancer patients using sonohysterography and MRI diffusion.
Shimaa Abdalla Ahmed, Hanan Ahmed El Taieb, Hesham Abotaleb   +2 more
doaj   +1 more source

Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology

International Journal of Molecular Sciences, 2018
The identification of new molecular targets and biomarkers associated with high risk of recurrence and response to therapy represents one of the main clinical challenges in the management of advanced disease in endometrial cancer.
L. Muinelo-Romay, Carlos Casas-Arozamena, M. Abal   +2 more
semanticscholar   +1 more source

Which is the most accurate diagnostic procedure in Tamoxifen treated breast cancer patients [PDF]

, 2018
Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in women treated ...
De Santis, A., Di Cello, P., Izzo, L., Izzo, P., Izzo, S., Millarelli, F., Pugliese, F., Razionale, F., Scarano Catanzaro, V.   +8 more
core  

Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]

, 2015
Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C, Casarin, A, Indraccolo, Stefano, Nardin, M, Nicoletto, Mo, Pomerri, Fabio, Randon, G, Zulato, E   +7 more
core   +1 more source

Detecting TP53 mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma

International Journal of Cancer, EarlyView.
What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja, Peter Micallef, Maria Lycke, Tobias Österlund, Manuel Luna Santamaría, Julia Hedlund Lindberg, Therese Carlsson, Ulf Gyllensten, Anders Ståhlberg, Benjamin Ulfenborg, Anna Linder, Karin Sundfeldt   +11 more
wiley   +1 more source