Results 111 to 120 of about 4,877,549 (387)

Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer.

New England Journal of Medicine, 2019
BACKGROUND Stage III or IVA endometrial cancer carries a significant risk of systemic and locoregional recurrence. METHODS In this randomized phase 3 trial, we tested whether 6 months of platinum-based chemotherapy plus radiation therapy ...
D. Matei, V. Filiaci, M. Randall, D. Mutch, M. Steinhoff, P. DiSilvestro, K. Moxley, Y. M. Kim, M. Powell, D. O’Malley, N. Spirtos, W. Small, K. Tewari, W. E. Richards, J. Nakayama, U. Matulonis, Helen Q. Huang, D. Miller   +17 more
semanticscholar   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

The Role of Metabolic Syndrome in Endometrial Cancer: A Review

Frontiers in Oncology, 2019
Endometrial cancer is one of the most common cancers of the female reproductive system. Although surgery, radiotherapy, chemotherapy, and hormone therapy can significantly improve the survival of patients, the treatment of patients with very early ...
Xiao Yang, Jianliu Wang
doaj   +1 more source

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Nature Cell Biology, 2018
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer.
J. Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu, Kangkang Yu, Samantha M. Tienda, Agnieszka Chryplewicz, Allen C. Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhigao Xu, X. Leng, Xue Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, E. Lengyel, Chuan He   +19 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

Dysbiosis of the endometrial microbiota and its association with inflammatory cytokines in endometrial cancer

International Journal of Cancer, 2020
The underlying molecular mechanisms involved in the pathogenesis of endometrial cancer (EC) are still not well understood. Our goal was to investigate the composition of the endometrial microbiota and the association with inflammatory cytokines in EC ...
Wanting Lu, F. He, Zheng Lin, Shuang Liu, Li Tang, Yuxiu Huang, Zhijian Hu   +6 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Risk Factors for Endometrial Cancer in the World: A Narrative Review of the Recent Literature

Clinical and Experimental Obstetrics & Gynecology
Objective: Endometrial cancer is the sixth most common cancer in women. Extensive studies have been conducted around the world to determine the risk factors of endometrial cancer.
Hamid Salehiniya, Leila Allahqoli, Zohre Momenimovahed   +2 more
doaj   +1 more source

Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]

, 2015
Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C, Casarin, A, Indraccolo, Stefano, Nardin, M, Nicoletto, Mo, Pomerri, Fabio, Randon, G, Zulato, E   +7 more
core   +1 more source