Results 111 to 120 of about 141,167 (306)

Pharmacological Management of Endometrial Cancer [PDF]

Endometrial cancer is one of the most common gynaecological malignancies. Women of post-menopausal age are most commonly affected, presenting with abnormal uterine bleeding.
Thom-Manuel, Sarah
core  

Endometrial carcinoma in elderly patients [PDF]

, 2016
The incidence of endometrial cancer is developing in subpopulation of aging women. This disease is much more aggressive in elderly women than younger ones.
Tran Le, Anh Thu
core  

Tumor-suppressor role of miR-139-5p in endometrial cancer

Cancer Cell International, 2018
Background Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Several study’s show that
JinHui Liu, ChunYu Li, Yi Jiang, YiCong Wan, ShuLin Zhou, WenJun Cheng   +5 more
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Synchronous Primary Cancers of the Endometrium and Ovary [PDF]

, 2011
Simultaneous detection of malignancy in the endometrium and ovary represents an uncommon event. The objective of the study was to clarify the possible factors that influenced on the survival.
CHIANG, YING-CHENG;CHEN, CHI-AN;HUANG, CHIA-YEN;HSIEH, CHANG-YAO;CHENG, WEN-FANG, 江盈澄;陳祈安;黃家彥;謝長堯;鄭文芳   +1 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. [PDF]

, 2016
BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we
Gorman, M, Hillemanns, Peter, Hopper, John L., Hall, P, Werner, Henrica MJ, Couch, Fergus J, Durst, M, Werner, HM, Tomlinson, I, Peto, Julian, Holliday, Elizabeth G., Webb, PM, Marquart, Louise, Scott, Rodney J., Giles, GG, Salvesen, Helga B, Australian National Endometrial Cancer Study Group (ANECS),, Werner, Henrica M. J., Easton, Douglas F, Tham, E, Bolla, Manjeet K, Hein, A, Cheng, Timothy, Annibali, D, Thompson, DJ, Hopper, John L, Beckmann, Matthias W., Hall, Per, Holliday, Elizabeth G, Lindblom, Annika, Lindblom, A, Meindl, Alfons, Salvesen, Helga B., Dowdy, SC, O'Mara, Tracey A., Proietto, A, Thompson, Deborah J, Attia, J, Njølstad, Tormund S., Ashton, KA, Rübner, Matthias, Wang, Qin, Njølstad, Tormund S, Swerdlow, AJ, Giles, Graham G., for RENDOCAS,, Couch, FJ, Fasching, PA, Fridley, Brooke L., Hodgson, SV, Meindl, A, Proietto, Anthony, Hopper, JL, Beckmann, Matthias W, Ekici, Arif B., Ashton, Katie A, National Study of Endometrial Cancer Genetics Group (NSECG),, Lambrechts, Diether, Pharoah, Paul D.P., Hein, Alexander, Wang, Q, Czene, Kamila, Dunning, Alison M, Healey, Catherine S., Spurdle, Amanda B., Tomlinson, Ian, Ahmed, S, Mints, Miriam, Scott, RJ, Spurdle, AB, Li, Jingmei, Dunning, AM, Giles, Graham G, Bolla, Manjeet K., Neven, Patrick, Czene, K, Burwinkel, B, Amant, Frederic, Goode, Ellen L, Easton, DF, McEvoy, Mark, Otton, G, Bolla, MK, for RENDOCAS, Tyrer, Jonathan P., Neven, P, National Study of Endometrial Cancer Genetics Group (NSECG), Darabi, H, Webb, Penelope M., Beckmann, MW, Medland, Sarah E, Painter, JN, Martin, L, Dennis, Joe, Kristensen, Vessela N, Swerdlow, Anthony J., Tyrer, JP, Cheng, T, Fridley, BL, O'Mara, Tracy A, Healey, CS, Njolstad, Tormund S., Burwinkel, Barbara, Painter, Jodie N, Brenner, H, Pharoah, PDP, Holliday, EG, Michailidou, Kyriaki, Cunningham, Julie M., Medland, Sarah E., Darabi, Hatef, Dowdy, Sean C., Easton, Douglas F., Winham, Stacey J., Pharoah, Paul DP, Spurdle, Amanda B, Painter, Jodie N., Runnebaum, IB, Kristensen, VN, Scott, Rodney J, Gorman, Maggie, Healey, Catherine S, Tham, Emma, Chang-Claude, J, Amant, F, Hodgson, Shirley V, Ashton, Katie A., Couch, Fergus J., Tyrer, Jonathan P, Dowdy, Sean C, Cunningham, JM, Fasching, Peter A., Fridley, Brooke L, Dork, T, Thompson, Deborah J., Rübner, M, Cunningham, Julie M, Salvesen, HB, Annibali, Daniela, Hodgson, Shirley V., Werner, HMJ, Runnebaum, Ingo B, Dörk, Thilo, Marquart, L, Dunning, Alison M., Hillemanns, P, Li, J, Dennis, J, Winham, SJ, Cox, A, Pharoah, Paul D. P., Runnebaum, Ingo B., Michailidou, K, AOCS Group, Chang-Claude, Jenny, Depreeuw, J, Attia, John, Ekici, AB, Australian National Endometrial Cancer Study Group (ANECS), Ahmed, Shahana, Medland, SE, Shah, M, Brauch, H, Trovik, Jone, Webb, Penelope M, Swerdlow, Anthony J, Peto, J, Fasching, Peter A, Brauch, Hiltrud, Cox, Angela, Njølstad, TS, Brenner, Hermann, Trovik, J, Martin, Lynn, Kristensen, Vessela N., McEvoy, M, Njolstad, TS, Goode, Ellen L., Depreeuw, Jeroen, Lambrechts, D, O'Mara, Tracy A., Ekici, Arif B, Otton, Geoffrey, Goode, EL, Dürst, Matthias, O'Mara, TA, Mints, M, Werner, Henrica M.J., Shah, Mitul, Winham, Stacey J, AOCS Group,   +190 more
core   +2 more sources

MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway

Frontiers in Medicine
ObjectiveUnderstanding the mechanisms underlying endometrial cancer progression is crucial for the development of effective targeted therapies. In this study, we investigated the role of MTFR2 in endometrial cancer cell.MethodsThe expression of MTFR2 in ...
Zhijun Niu, Yue Zhang, Yishan Wang, Dongxia Liu, Junmin Wang, Tingting Shi, Xia Xu, Lei Li   +7 more
doaj   +1 more source

Endometrial cancer: asymptomatic endometrial findings. Characteristics of postmenopausal endometrial cancer.

European journal of gynaecological oncology, 2005
Endometrial cancer affects patients at every age, however it occurs more frequently in menopause (> 50) and in postmenopause (> 70). The most frequent symptoms are bleeding and vaginal discharge. When hematometra or pyometra is present the patient may feel pain. In some cases endometrial adenocarcinoma is asymptomatic and the diagnosis is casually made
MARCHETTI M., VASILE C., CHIARELLI, SILVIA   +2 more
openaire   +2 more sources

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source