Results 181 to 190 of about 127,260 (361)

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács   +13 more
wiley   +1 more source

Rapid Induction of Endometrial Carcinoma in ICR Mice Treated with N‐Methyl‐N‐nitrosourea and 17β‐Estradiol [PDF]

open access: hybrid, 1991
Kenji Niwa   +6 more
openalex   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

open access: yesCancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo   +14 more
wiley   +1 more source

Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line [PDF]

open access: green, 1990
Seija Grénman   +8 more
openalex   +1 more source

The Growing Burden of Obesity: Addressing a Global Public Health Challenge

open access: yes
United European Gastroenterology Journal, EarlyView.
Patrizia Burra   +11 more
wiley   +1 more source

Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells

open access: yesCancer Science, EarlyView.
We profiled genome‐wide DNA methylation in 1165 human cancer cell lines representing 25 cancer types and identified 73 genes as potential liver cancer‐specific methylation‐silenced genes. We selected ASNS, BCAT2, FXYD5, and NQO1 genes for further experimental analysis and demonstrated that aberrant methylation of BCAT2 contributes to the vulnerability ...
Karen Minowa   +3 more
wiley   +1 more source

RCdpia: A Renal Carcinoma Digital Pathology Image Annotation dataset based on pathologists [PDF]

open access: yesarXiv
The annotation of digital pathological slide data for renal cell carcinoma is of paramount importance for correct diagnosis of artificial intelligence models due to the heterogeneous nature of the tumor. This process not only facilitates a deeper understanding of renal cell cancer heterogeneity but also aims to minimize noise in the data for more ...
arxiv  

Primary carcinoma of the Fallopian tube with positive vaginal, endometrial and culde-sac smears

open access: bronze, 1977
Shigeo Masubuchi   +8 more
openalex   +2 more sources

Clonal Hematopoiesis and Solid Cancers

open access: yesCancer Science, EarlyView.
This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen   +3 more
wiley   +1 more source

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