Results 31 to 40 of about 92,477 (262)

CYLD expression in endometrial carcinoma and correlation with clinicohistopathological parameters

Taiwanese Journal of Obstetrics & Gynecology, 2022
Objective: Endometrial cancer is a threat to women health worldwide. Cylindromatosis (CYLD) enzyme is a tumour suppressor, considered an effective prognostic marker in various malignancies, but its role in endometrial carcinoma is not fully elucidated ...
Vasiliki Papadatou, Stylianos Tologkos, Avgi Tsolou, Theodora-Eleftheria Deftereou, Anastasios Liberis, Grigorios Trypsianis, Triantafyllos Alexiadis, Kyriaki Georgiadi, Christina-Angelika Alexiadi, Christina Nikolaidou, Maria Lambropoulou   +10 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Trans-vaginal sono-elastography in the differentiation of endometrial hyperplasia and endometrial carcinoma

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
Aim: To evaluate efficiency of sono-elastography in differentiation of endometrial hyperplasia and endometrial carcinoma. Patients and methods: Between January 2014 and January 2015, 45 perimenopausal female patients with endometrial thickness more than ...
Mahmoud Abdel Latif, Magda Shady, Hanan Nabil, Yasser Mesbah   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

SMARCA4-deficient undifferentiated carcinoma co-existing with primary endometrial gastric (or gastrointestinal) -type carcinoma: a case report

Frontiers in Oncology
Dedifferentiated endometrial carcinoma (DEC) is a rare and highly malignant endometrial tumor consisting of both undifferentiated endometrial carcinoma (UEC) and differentiated components (that are typically grade 1 or 2 endometrioid carcinomas).
Fan Yang, Haixiao Fu, Xiang Zheng, Yuzhong Yang, Quyan Zhou, Yuanna Liang, Jinhua Zheng, Jing Lin   +7 more
doaj   +1 more source

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium

BMC Cancer, 2022
Background This study observed and described the morphological characteristics of the endometrium of the resected uterus using confocal laser endomicroscopy.
Jia Wen, Xi Yang, Guiying Ye, Rui Chen, Yu Feng, Qinping Liao   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight

Journal of Family and Reproductive Health, 2021
Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC ...
Amrita Talwar, Pushpanjali Behera, Arvind Ahuja, Bani Sarkar, Ravi Hari Phulware   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source