Results 131 to 140 of about 679 (269)
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 87-94, January 2023., 2023 Abstract Dostarlimab (JEMPERLI) is an anti‐programmed cell death protein‐1 (PD‐1) monoclonal antibody (mAb) which is approved by the US Food and Drug Administration for patients with recurrent/advanced mismatch repair‐deficient solid tumors, including endometrial cancer, following progression on prior treatment, with approval based on data from the ...
Daren Austin +4 more
wiley +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications
Small, Volume 18, Issue 51, December 22, 2022., 2022 Hyaluronic acid (HA) is a very promising polysaccharide for biomedical applications. This review provides a comprehensive overview of the development of nanoparticulate systems by HA‐based polyelectrolyte complexation. The main achievements and applications for the delivery of active substances or the construction of multifunctional platforms are ...
Huu Van Le, Didier Le Cerf
wiley +1 more source
International Journal of Cancer, EarlyView.Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder +2 more
wiley +1 more source
Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer
International Journal of Cancer, EarlyView.What's New? In this prospective study, the authors evaluated the discrimination capacity of 92 cancer‐related proteins as potential early detection biomarkers for endometrial cancer using blood samples from two large‐scale European population cohorts (EPIC and Janus).
Victoria Cooley +12 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita +12 more
wiley +1 more source
Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients
International Journal of Cancer, EarlyView.What's New? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini +18 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? Currently, no published data on homologous recombination deficiency (HRD) testing in the setting of molecular tumor boards exist. This study in a cohort of 237 patients encompassing 24 different tumor entities assessed by a molecular tumor board shows that inactivating alterations of BRCA1/2 are not always associated with an elevated ...
Christoph Schubart +26 more
wiley +1 more source
Stump pyometra in a spayed female dog secondary to tamoxifen
Veterinary Medicine and Science, Volume 9, Issue 1, Page 47-52, January 2023., 2023 A 2‐year‐old spayed female dog treated successfully for sclerosing encapsulating peritonitis for 11 months with tamoxifen, cyclosporine, and a short‐term course of prednisone began developing signs of enlarged vulva and discharge. A stump pyometra was confirmed on ultrasound and computed tomography and exploratory laparotomy was performed to remove the
Caryn Ehrhardt +5 more
wiley +1 more source