Results 151 to 160 of about 75,548 (336)

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, EarlyView.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome

International Journal of Cancer, EarlyView.
What's New? Lynch syndrome is a prevalent cause of hereditary gynecological cancers, but the timeline of molecular alterations preceding malignancy remains unclear. By studying consecutive surveillance specimens for up to 15 years before cancer diagnosis, the authors found that atypical endometrial hyperplasia was indistinguishable from endometrial and
Anni K. Kauppinen, Alisa P. Olkinuora, Jukka‐Pekka Mecklin, Päivi T. Peltomäki   +3 more
wiley   +1 more source

Pembrolizumab in programmed death ligand 1-positive endometrial cancer [PDF]

, 2017
BENEDETTI PANICI, Pierluigi, Tomao, Federica, Tomao, Silverio   +2 more
core   +1 more source

Clinical and genetic features of multiple primary tumours cohorts with a renal cell carcinoma: Implications for molecular genetic investigations

International Journal of Cancer, EarlyView.
What's New? Current knowledge of the genetic architecture underlying the development of renal cell carcinoma‐related multiple primary tumours is limited. The authors comprehensively analysed the results of exome/genome sequencing cohorts including 534 patients to better define genotype–phenotype correlations.
Huairen Zhang, Bryndis Yngvadottir, Avgi Andreou, Yasemin Cole, Emma R. Woodward, James Whitworth, Eamonn R. Maher   +6 more
wiley   +1 more source

The Value of DNA Quantitative Cytology Test for the Screening of Endometrial Cancer

Cancer Management and Research, 2019
Bao-hua Yang,1 Ming-xia Yu,1 Jun Xu,1 Yan Su,1 Zhi-hong Ai2 1Department of Obstetrics and Gynecology, Shanghai Minhang Central Hospital, Shanghai 201199, People’s Republic of China; 2Department of Obstetrics and Gynecology, Shanghai Jiao Tong ...
Yang B, Yu M, Xu J, Su Y, Ai Z
doaj  

Integrative omics approaches to uncover liquid‐based cancer‐predicting biomarkers in Lynch syndrome

International Journal of Cancer, EarlyView.
What's New? Lynch syndrome (LS) significantly increases lifetime cancer risk, necessitating innovative approaches for risk stratification. Current risk assessment methods, however, fail to integrate data from different biological systems, which may be influenced by lifestyle factors.
Minta Kärkkäinen, Tero Sievänen, Tia‐Marje Korhonen, Joonas Tuomikoski, Kirsi Pylvänäinen, Sami Äyrämö, Toni T. Seppälä, Jukka‐Pekka Mecklin, Eija K. Laakkonen, Tiina Jokela   +9 more
wiley   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Malignant mixed Müllerian tumor

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Uterine carcinosarcomas or malignant mixed Müllerian tumors are rare neoplasms. They have an aggressive behavior and the prognosis depends mainly on the stage of the disease at the time of diagnosis. The progression of these tumors is unfavorable despite
Javier Martínez-Navarro, Caridad Socorro-Castro, Dianarelys Villafuerte-Delgado   +2 more
doaj  

Do MRI structured reports with FIGO classifications of leiomyomas contain adequate information for clinical decision making?

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate if structured reports (SR) of pelvic magnetic resonance imaging (MRI) scans using the PALM‐COEIN FIGO (the International Federation of Gynecology & Obstetrics) uterine leiomyomas classification (SR‐FIGO) contain adequate information for clinical decision making compared with narrative reports (NR). Methods Three reporting
Laura Tordjman, Haleh Amirian, Alexandra Alvarez, Sara Shir, Julieta Aristizabal, Patricia Castillo, Prasoon Mohan, Stephanie Delgado, Francesco Alessandrino   +8 more
wiley   +1 more source