Results 171 to 180 of about 679 (269)

Identification of PPFIA3 as a Potential Prognostic and Immune Biomarker Through Pan‐Cancer Analysis

Organ Medicine, EarlyView.
This study reveals a significant increase in the expression of PPFIA3 across various cancers, which is associated with poor prognosis. Notably, in patients receiving anti‐PD‐L1 treatment, high PPFIA3 expression is closely linked to improved survival rates and favorable prognosis, suggesting its potential as a predictive factor for immune checkpoint ...
Xianghong Wang, Rong Lin, Chuanchuan Sun, Niujian Wu, Hongyun Lu   +4 more
wiley   +1 more source

Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma

The Journal of Pathology, EarlyView.
Abstract Tumor protein p53 mutated/abnormal (p53abn) endometrial carcinomas account for over 50% of deaths but comprise only 15% of all endometrial carcinomas. Most patients show limited response to standard‐of‐care chemotherapy with or without radiotherapy, and only a minority of cases are amenable to targeted therapies like poly‐ADP ribose polymerase
Spencer D Martin, Shelby Thornton, Christine Chow, Katy Milne, Juliana Sobral de Barros, Kayleigh A Morris, Samuel Leung, Amy Jamieson, Brad H Nelson, Dawn R Cochrane, David G Huntsman, C Blake Gilks, Lien Hoang, Jessica N McAlpine, Allen W Zhang   +14 more
wiley   +1 more source

Application of high‐dose‐rate endorectal brachytherapy in the treatment of locally advanced rectal cancer

Precision Radiation Oncology, EarlyView.
This image compares the studies included in this article with the meta‐analysis from the Cochrane Library, indicating that the incorporation of brachytherapy in neoadjuvant treatment for rectal cancer can achieve better pathological response rates. Additionally, the use of brachytherapy can reduce the local recurrence rate in patients.
Tianyao Wang, Yifan Tao, Guanghui Gan, Long Chen, Yuan Xu, Fei Sun, Xiaoting Xu   +6 more
wiley   +1 more source

Kussmaul's Sign Provoked by Intracardiac Metastasis of Endometrial Neuroendocrine Tumor

The Kaohsiung Journal of Medical Sciences, EarlyView.
Yi‐Hsun Chen, Chin‐Chuan Chang, Yao‐Kuang Wang, I‐Chen Wu   +3 more
wiley   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, EarlyView.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediated glycan modulation

VIEW, EarlyView.
Infertility is a global concern, with male factors contributing to nearly half of cases. This study compared glycopatterns of sperm and sperm‐derived exosomes from conventional IVF and rescue ICSI (RICSI) patients, revealing key differences in glycan expression.
Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu   +10 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Diagnosis and successful treatment of open pyometra in a wild European brown hare (Lepus europaeus)

Veterinary Record Case Reports, EarlyView.
Abstract This case report describes an open pyometra in a wild adult female hare (Lepus europaeus) that was rescued in the Umbria countryside (Italy) during mid‐January. The clinical signs observed included anorexia and a mucopurulent to haemorrhagic discharge from the vulva.
Claudia Massone, Oriana Cianca, Isabella Costantino, Daniele Marini, Domenico Caivano   +4 more
wiley   +1 more source

Non‐primary adenocarcinoma in a pet goat (Capra hircus)

Veterinary Record Case Reports, EarlyView.
Abstract A 12‐year‐old hysterectomised pet goat was referred for posterior lameness and general weakness evolving into paralysis. Spine radiography showed a sublumbar mass and a vertebral fracture. The computed tomography scan and postmortem examination further confirmed the presence of sublumbar adenocarcinoma infiltrating vertebrae and inducing a ...
Faten Bouaicha, Joanna Sayah, Nathalie Cordonnier, Bérangère Ravary‐Plumioën   +3 more
wiley   +1 more source