Results 231 to 240 of about 93,286 (337)

Gynecological Cancer Oncobiome Systematic Review. [PDF]

Cancers (Basel)
Łatkiewicz T, Rasoul-Pelińska K, Kułak K, Tarkowski R, Kułak A, Puzio I.   +5 more
europepmc   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. [PDF]

Sci Rep
Soykan Y, Yar Saglam AS, Inan MA, Ugras Dikmen A, Erdem Ö, Onan MA.   +5 more
europepmc   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

DNA Methylation in Ovarian and Endometrial Cancers: Predictive and Mechanistic Roles in PARP Inhibitor and ICI Response

Cancer Science, EarlyView.
Cancer treatment is shifting from an organ‐based framework to one driven by biological phenotypes, and DNA methylation is increasingly recognized as an important factor that governs tumor behavior beyond genetic mutations. In gynecologic cancers, BRCA1 and MLH1 promoter methylation–associated homologous recombination deficiency and mismatch repair ...
Shuhei Kitamura, Ayumi Taguchi, Kana Tamai, Yoko Yamamoto, Anh Quynh Duong, Daisuke Yoshimoto, Ayako Mori, Aya Ishizaka, Saki Tsuchimochi, Kenbun Sone, Masahito Kawazu, Katsutoshi Oda, Yasushi Hirota   +12 more
wiley   +1 more source

Physicians' Controversies Towards Fertility Preservation in Young Patients with Gynecological Cancer: An MITO Survey. [PDF]

Curr Oncol
Corrado G, Peters I, Silvestris E, Cioffi R, Iacobelli M, Mancini E, Vizza R, Thiella S, Cormio G, Pignata S, Mangili G.   +10 more
europepmc   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, EarlyView.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

The Female Reproductive Tract Microbiota and Endometrial Cancer: A Systematic Review. [PDF]

Int J Mol Sci
Vizza R, Belli F, Fabene P, Salari V, Casprini C, Corrado G, Laganà AS, Zorzato PC, Bosco M, Porcari I, Uccella S, Garzon S.   +11 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

A nomogram for the prediction of endometrial cancer in postmenopausal women with a thickened endometrium. [PDF]

BMC Womens Health
Ai F, Zhu H, Wang C, Zhou L, Wang S.
europepmc   +1 more source