Results 241 to 250 of about 75,548 (336)

Blurring the Lines: Co‐Occurrence of MSH6 Variant and MLH1 Constitutional Epimutation in a Young Colorectal Cancer Patient

Clinical Genetics, EarlyView.
We report a unique case of early‐onset colorectal cancer with both a germline MSH6 variant and constitutional mosaic MLH1 epimutation, revealing a possible digenic mechanism underlying Lynch syndrome. This case highlights the diagnostic complexity of mismatch repair deficiency and the value of integrative tumor–germline molecular profiling.
Aasem Abu Shtaya, Yarin Hadid, Ahmad Mahamid, Debora Kidron, Naama Halpern, Adel Shalata, Zohar Levi, Yael Goldberg   +7 more
wiley   +1 more source

A Rare Case of Large Ovarian Thecoma Diagnosed Histopathologically Following Surgical Management in a Premenopausal Woman: A Case Report and Review of the Current Literature. [PDF]

Clin Case Rep
Lugata J, Makower L, Rapheal A, Kaleshu J, Lyamuya T, Mchome B, Mremi A.   +6 more
europepmc   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, EarlyView.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source

A Strange Case of Fever: Hematopyometra As the Initial Presentation of Endometrial Adenocarcinoma. [PDF]

Cureus
Mandim A, Silva AS, Moça R, Faria L, Ribeiro F, Silva R.   +5 more
europepmc   +1 more source

Establishment and Validation of a C57BL/6J Mouse Model for Melasma

Cell Proliferation, EarlyView.
A melasma‐like mouse model was established in C57BL/6J mice using a combination of UVB irradiation, progesterone administration, and chronic psychological stress. This model replicates key clinical features and biomarker alterations observed in human melasma. Importantly, it is fundamentally distinct from UV‐induced post‐inflammatory hyperpigmentation (
Wenzhu Wang, Xiaojie Sun, Yunyao Liu, Yin Yang, Hedan Yang, Xiaoli Zhang, Xiuzhen Li, Haoxiang Xu, Xu Chen, Tong Lin   +9 more
wiley   +1 more source

Increased colorectal and endometrial cancer rates in a genomically ascertained Lynch syndrome cohort. [PDF]

JNCI Cancer Spectr
Hallquist MLG, Savatt JM, Diloreto K, Johns A, Decker A, Hayes C, Kelly MA, Kirchner HL, Strande NT, Buchanan AH.   +9 more
europepmc   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Expression of hormonal receptors and Toll-like receptors in cultured canine uterine explants with pseudoplacentational endometrial hyperplasia and bacterial-elicited endometrial inflammation. [PDF]

PLoS One
Santana CH, Souza MFS, Silva L, Souza LDR, Oliveira AR, Borges ÁM, Paixão T, Santos RL.   +7 more
europepmc   +1 more source

The Methylation Test Is Highly Sensitive for HPV‐Associated Endocervical Adenocarcinoma and Could Be Helpful as a Cytological Ancillary Test in Women With a PAP‐Smear Diagnosis of Severe Glandular Lesion (AGC–NEO+)

Cytopathology, EarlyView.
Based on an analysis of 85 endocervical adenocarcinoma (EA) cases with cytology–histology correlation, the authors document a methylation test sensitivity of 95.3% for diagnosing EA. If used as an ancillary test, the methylation test may improve the PAP test's reliability.
Iva Kinkorová Luňáčková, Ondrej Ondič, Jana Němcová, Kateřina Černá, Jan Chytra, Jiří Bouda   +5 more
wiley   +1 more source