Results 71 to 80 of about 236,724 (287)

The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature

open access: yesGynecology Obstetrics & Reproductive Medicine, 2015
Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium.
Salih Taşkın   +4 more
doaj  

Rare neoplasms

open access: yes, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
Valentina Ciaravino   +11 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

open access: yesAdvanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long   +12 more
wiley   +1 more source

Znaczenie polimorfizmu pojedynczych nukleotydów Arg399Gln genu XRCC1 w raku endometrium u polskich kobiet w wieku pomenopauzalnym

open access: yesMenopause Review, 2011
Background: Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial ...
Hanna Romanowicz-Makowska   +5 more
doaj  

A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors

open access: yesFrontiers in Oncology
BackgroundUterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other ...
Xinyao Wan   +3 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

open access: yesAdvanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao   +19 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

open access: yesAdvanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang   +5 more
wiley   +1 more source

Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome

open access: yesBladder Cancer, 2018
Background: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome.
Dora Huang   +3 more
doaj   +1 more source

Sarcoma do Estroma Endometrial (SEE). Factores de prognóstico clínicos e patológicos.

open access: yesActa Médica Portuguesa, 1997
Endometrial Stromal Sarcomas are rare neoplasms, accounting for 0.2% of female genital tract malignancies. They occur predominantly in post menopausal women, although they can develop during the reproductive years or even in childhood. The most important
I Paiva   +8 more
doaj   +1 more source

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]

open access: yes, 2011
Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti   +14 more
core   +1 more source

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