Results 51 to 60 of about 86,874 (288)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Dysgerminoma and granulosa cell tumor in a bitch

Brazilian Journal of Veterinary Pathology, 2016
Dysgerminoma and granulosa cell tumor are neoplasms of the ovary of domestic animals, originating from germ cells and sex-cords cells, respectively. These neoplasms generally occur unilaterally, and usually as a single neoplasm.
Ayisa R. Oliveira, Mayra C. Flecher, Flávia F. Jabour, Tayse D. Souza, Isabela Hardt, Fernanda T. Vieira, Alice C. Rassele, Gabriel C. Vicente, Flávia M. Machado   +8 more
doaj   +1 more source

Sentinel Lymph Node Biopsy in Endometrial Cancer – A Systematic Review and Quality Assessment of Meta-Analyses

Revista Brasileira de Ginecologia e Obstetrícia, 2022
Objective To assess the quality of recent meta-analyses reviewing the diagnostic utility of sentinel node biopsy in endometrial cancer. Methods With the MeSH terms endometrial neoplasms and sentinel lymph node biopsy, PubMed and Embase databases were ...
Mario Arturo González Mariño
doaj   +1 more source

Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp

, 2005
Background. Metastasis of extragenital neoplasms to an endometrial polyp is rare and until now, only 6 cases of such involvement has been ...
Oner, U, Tekin, B, Yavuz, E, Acikalin, MF, Cengiz, O   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Silent Intruder: Diagnosing and Managing a Uterine Polyp in a Young Female [PDF]

Journal of Clinical and Diagnostic Research
Endometrial polyps are asymptomatic benign neoplasms of the uterine lining that often result in Abnormal Uterine Bleeding (AUB), an illness that is frequently encountered in clinical practice [1].
Sheetal Asutkar, Ayushi Gautam, Shipla Jamdade   +2 more
doaj   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Carcinosarcoma of uterus

Radiology Case Reports, 2023
Uterine carcinosarcoma, which is categorized as high-grade endometrial cancer, is an uncommon kind of malignant gynecological neoplasms. Clinically, this tumor frequently affects menopausal women and the main symptom is abnormally postmenopausal vaginal ...
Ho Xuan Tuan, MD, PhD, Nguyen Minh Duc, MD, Cao Minh Tri, MD, Huynh-Thi Do Quyen, MD, Pham Xuan Dung, MD, PhD   +4 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Breast metastasis in high-grade endometrial stromal sarcoma (HG-ESS) with BCOR rearrangement: a case report of a novel metastatic site

Diagnostic Pathology, 2023
Background The ZC3H7B-BCOR fusion gene has recently been described in tumours with kinship to so-called high grade endometrial stromal sarcoma (HG-ESS).
Ashlyn Fong, Saul Offman
doaj   +1 more source