Results 41 to 50 of about 86,874 (288)

Association of membranous WNT-1 and nuclear mTOR with endometrial cancer grade

, 2023
Endometrial cancer remains a common cancer affecting the female reproductive system. There is still a need for more efficient ways of determining the degree of malignancy and optimizing treatment.
Waligóra, Marcin, Pityński, Kazimierz, Skrzypek, Klaudia, Marcin Waligora, Ludwin, Artur, Socha, Maciej W., Kazimierz Pitynski, Katarzyna Milian-Ciesielska, Klaudia Skrzypek, Pietrus, Miłosz, Milian-Ciesielska, Katarzyna, Milosz Pietrus, Artur Ludwin, Maciej W. Socha   +13 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Prevalence of neoplasms in patients with acromegaly – the need for a national registry

, 2018
Introduction Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1).
Jolanta Kowalczyk-Bołtuć, Kowalczyk-Bołtuć, J., Marcin Lewicki, Obel, E., Matyjaszek-Matuszek, B., Agata Smoleń, Beata Matyjaszek-Matuszek, Smoleń, A., Ewa Obel, Lewicki, M.   +9 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Synchronous Endometrial and Ovarian Adenocarcinomas in a 43-Year-Old Patient Following Infertility Treatment: A Case Report

Diagnostics
Background and Clinical Significance: This study presents a case of a 43-year-old female with a long history of infertility, treated for uterine leiomyoma and endometrial hyperplasia, over a total observation period of 42 months.
Małgorzata Gajewska, Barbara Suchońska, Joanna Blok, Wanda Gajzlerska-Majewska, Artur Ludwin   +4 more
doaj   +1 more source

Malignancy Risk of Endometrial Polyps Among Geriatric Women

International Journal of Gerontology, 2018
Summary: Background: The population of elderly women is increasing worldwide. Here we investigated the prevalence of malignant endometrial polyps in a population of geriatric women.
Burcu Kisa Karakaya, Nazlı Topfedaisi Ozkan, Hatice Kansu-Celik, Bugra Coskun, Erdinc Saridogan, Ozlem Evliyaoglu   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Involvement of chromosome 6 in endometrial cancer

, 1997
Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases.
M Trubia, C Capella, D Furlan, TARAMELLI, ROBERTO, MG Tibiletti, CAPELLA, CARLO RENATO, Franchi, M., M Taborelli, FURLAN, DANIELA, Fabbri, A., Tibiletti, M. G., Trubia, M., Bernasconi, B., R Taramelli, B Bernasconi, A Fabbri, M Franchi, Taborelli, M.   +17 more
core   +1 more source

Multiple synchronous primary neoplasms of the breast, colon and rectum after surgery for endometrial cancer: A case report

, 2013
INTRODUCTIONEndometrial cancer survivors exhibit an increased incidence of subsequent neoplasms.PRESENTATION OF CASEWe present a patient with a history of endometrial cancer who, 3 years after surgery and radiotherapy, developed synchronous neoplasms of ...
Markakis, Charalampos, Voultsos, Mavroudis, Marinis, Athanasios, Grivas, Paraskevas, Rizos, Spyridon, Liarmakopoulos, Emmanouil, Zervogiannakou, Patritsia, Dikeakos, Panagiotis   +7 more
core   +1 more source