Results 81 to 90 of about 511,190 (325)

The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature

Gynecology Obstetrics & Reproductive Medicine, 2015
Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium.
Salih Taşkın, Emre Göksan Pabuçcu, Alper Kahraman, İbrahim Yalçın, Uğur Fırat Ortaç   +4 more
doaj  

Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer

Tumor Biology, 2018
Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński, Jerzy Bełtowski, Łukasz Nowakowski, Danuta Vasilevska, Tomasz Rechberger, Andrzej Semczuk   +5 more
doaj   +1 more source

EP06.05-03 Subpleural Cystic Mesenchymal Neoplasm with Endometrial-type Stromal Proliferation: A Report of 3 Cases [PDF]

, 2023
Peter B. Illei, John B. Gross, David Suster   +2 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Determining the Oestrogen and Progesterone Receptor Expression in Cases of Endometrial Carcinoma: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Endometrial carcinoma is the second most common female genital tract malignancy in India with a incidence rising globally. Hormone receptors are positive in 35-90% of endometrial carcinomas.
Resmi Rajeev, Nisha m das, CR jyothi
doaj   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Znaczenie polimorfizmu pojedynczych nukleotydów Arg399Gln genu XRCC1 w raku endometrium u polskich kobiet w wieku pomenopauzalnym

Menopause Review, 2011
Background: Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial ...
Hanna Romanowicz-Makowska, Beata Smolarz, Amer Houli, Bożena Góralczyk, Ireneusz Połać, Krzysztof Szyłło   +5 more
doaj  

A rare case report of uterine carcinosarcoma with bilateral ovarian Brenner tumors

Frontiers in Oncology
BackgroundUterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other ...
Xinyao Wan, Fangfang Bi, Bing Xin, Chong Qiao   +3 more
doaj   +1 more source

A Rare Case Report of Perivascular Epithelioid Cell Neoplasm (PEComa) In A 54-Year-Old Woman With Endometrial Polyp [PDF]

, 2023

openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source