Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo [PDF]
, 2010 Background Uterine sarcomas are very rare malignancies with no approved chemotherapy protocols. Histone deacetylase (HDAC) inhibitors belong to the most promising groups of compounds for molecular targeting therapy.
Andelko Hrzenjak +6 more
core +1 more source
Immunohistochemistry of endometrial stromal sarcoma
Human Pathology, 1991 Twenty-three cases (12 low grade, 11 high grade) of endometrial stromal sarcoma were studied with monoclonal antibodies to vimentin, keratin, desmin, muscle actin, epithelial membrane antigen, and collagen type IV, using the avidin-biotin immunoperoxidase method. Tumors were highly variable in the expression of these antigens.
A I, Farhood, J, Abrams
openaire +2 more sources
High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis
Cancer Management and Research, 2019 Objectives The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).
Yan-Yan Zhang +5 more
semanticscholar +1 more source
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients [PDF]
, 2016 Background Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study was to determine the presence and
Berthold Streubel +10 more
core +3 more sources
Primary colonic extrauterine endometrial stromal sarcoma: A case and review of the literature
Gynecologic Oncology Reports, 2020 Highlights • Primary colonic extrauterine endometrial stromal sarcoma is a rare entity and diagnosis of this tumor can be challenging.• There is a common gene translocation specific to the tumors, our case was confirmed by identifying it.• Classifying ...
K. Kundu +5 more
semanticscholar +1 more source
Beyond the chaos: How architecture structures tumour biology
The FEBS Journal, EarlyView.Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner +3 more
wiley +1 more source
Mixed low grade and high grade endometrial stromal sarcoma of uterus: Differences on immunohistochemistry and chromosome in situ hybridisation [PDF]
, 1996 A case of a 64 year old woman with a tumour of the uterus is reported. The patient presented with postmenopausal bleeding and subsequently underwent total hysterectomy and bilateral salpingooophorectomy.
Cheung, ANY, Chung, LP, Khoo, US, Ng, WF
core
UK guidelines for the management of soft tissue sarcomas [PDF]
, 2016 Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the ...
Dangoor, A +5 more
core +1 more source
Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang +4 more
wiley +1 more source