Results 41 to 50 of about 30,534 (142)

Multifactorial construction of low‐grade and high‐grade endometrial cancer recurrence prediction models

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To analyze independent risk factors for endometrial cancer (EC), a common female cancer globally, and construct individualized prediction models for EC recurrence. Methods The EC patients from the medical record system were divided into low‐grade (n = 392) and high‐grade (n = 183) groups.
Yachai Li, Jia Yan, Yuanmei Deng, Peixuan Wang, Xue Bai, Wei Qin   +5 more
wiley   +1 more source

Can dynamic contrast enhanced magnetic resonance imaging change treatment planning in endometrial carcinoma? [PDF]

, 2013
PurposeTo detect the diagnostic accuracy of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in the assessment of myometrium and cervix infiltration and lymph node (L.N) status in patients with endometrial carcinoma.Patients and ...
Abbas, Ahmed, Aly, Ahmed Mohamed, Moustafa, Yehia I., Shaaban, Hebatallah Mohamed   +3 more
core   +1 more source

Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy

iMetaOmics, EarlyView.
This study investigates the risk of thrombotic microangiopathy (TMA) induced by vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) inhibitors in cancer therapy. Using data from the FDA Adverse Event Reporting System (FAERS), the WHO Global Database for Adverse Drug Reactions (Vigibase), and The Cancer ...
Aimin Jiang, Zhanzhi Li, Ying Liu, Junyi Shen, Quan Cheng, Anqi Lin, Peng Luo, Linhui Wang   +7 more
wiley   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

PIK3CA mutations in advanced cancers: characteristics and outcomes. [PDF]

, 2012
PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics.
Falchook, Gerald S, Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S, Janku, Filip, Kurzrock, Razelle, Lee, Jack J, Luthra, Rajyalakshmi, Moulder, Stacy L, Naing, Aung, Piha-Paul, Sarina A, Stepanek, Vanda M, Tsimberidou, Apostolia M, Wheler, Jennifer J   +13 more
core   +4 more sources

Effects of Nonablative Er‐YAG Laser on Human Endometrial Stromal Cells (hESCs): A Pilot Study

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives To investigate the thermo‐chemical effects of nonablative Er:YAG laser on human endometrial stromal cells (hESCs). Materials and Methods In this laboratory based study, for the hESCs cultures, endometrial tissue biopsy samples were obtained from three fertile women in the late proliferative phase.
Cemal Tamer Erel, Duygu Neccar, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Elif Guzel Meydanli   +4 more
wiley   +1 more source

Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma

The Journal of Pathology, EarlyView.
Abstract Tumor protein p53 mutated/abnormal (p53abn) endometrial carcinomas account for over 50% of deaths but comprise only 15% of all endometrial carcinomas. Most patients show limited response to standard‐of‐care chemotherapy with or without radiotherapy, and only a minority of cases are amenable to targeted therapies like poly‐ADP ribose polymerase
Spencer D Martin, Shelby Thornton, Christine Chow, Katy Milne, Juliana Sobral de Barros, Kayleigh A Morris, Samuel Leung, Amy Jamieson, Brad H Nelson, Dawn R Cochrane, David G Huntsman, C Blake Gilks, Lien Hoang, Jessica N McAlpine, Allen W Zhang   +14 more
wiley   +1 more source

Whole Abdominal Radiotherapy Is Tolerable and Effective in Children and Young Adults With Intra‐Abdominal Sarcoma: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Whole abdominal radiotherapy (WART) is utilized in children, adolescents, and young adults with intra‐abdominal sarcoma, but efficacy and toxicity are uncertain. Methods Sarcoma patients diagnosed at ≤39 years of age between 1998 and 2023 who received WART were identified from a national registry.
Rebecca J. Deyell, Hagit Peretz Soroka, Delaney Sharp, Caroline Ruus, Jeffrey N. Bone, Mai‐Kim Gervais, Audrey Roux, Xiaolan Feng, Natalie Logie, Nicolas Prudhomme, Caroline Holloway, Abha A. Gupta, Derek S. Tsang   +12 more
wiley   +1 more source

Virilizing Leydig-Sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: Case report and general considerations [PDF]

, 2012
Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in ...
Autore, C, Chioma, L, Cicerone, E, Di Giacinto, P, Fabbri, A, Gnessi, L, Guccione, L, Mariani, S, Moretti, C, Ulisse, S, Vancieri, G   +10 more
core   +2 more sources

Comparative Analysis of the Progesterone Receptor Interactome in the Human Ovarian Granulosa Cell Line KGN and Other Female Reproductive Cells

PROTEOMICS, EarlyView.
ABSTRACT The nuclear steroid hormone receptor progesterone receptor (PGR) is expressed in granulosa cells in the ovarian follicle in a tightly regulated pattern in response to the surge of luteinizing hormone (LH) that stimulates ovulation. PGR plays a critical role in mediating ovulation in response to LH, however, the mechanism for this is still ...
Natalie J. Foot, Doan T. Dinh, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Darryl L. Russell   +5 more
wiley   +1 more source