Results 51 to 60 of about 911,945 (271)
Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration
Advanced Science, EarlyView.A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang +9 morewiley +1 more sourceFine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. [PDF]
, 2014 Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene ...Olson, J.E., Spurdle, A.B., Schrauwen, S., Doerk, T., Hall, P, CHIBCHA Consortium, Werner, HM, Webb, PM, Tzortzatos, G., Long, J., Liu, J., Hein, A, Amant, F., Tomlinson, I., Ruebner, M, Attia, J., McEvoy, M., Shu, X.-O., Rojas-Martinez, A, Martin, N.G., Zheng, W., Proietto, T, Dieffenbach, AK, Rudolph, A, Meindl, A., Swerdlow, A.J., Dunning, A.M., Santos, E., Dowdy, SC, Ferguson, K, Batra, J., Tyrer, J.P., De Polanco, MM, Lambrechts, D., Pollock, P, Salvesen, H.B., Hopper, JL, Coenegrachts, L., Fasching, P.A., Runnebaum, I., Michailidou, K., Ekici, A.B., Wang, Q, Batra, J, Johnson, N., Henders, AK, Canc, ANE, Marme, F., Ferguson, K., Montgomery, G.W., Ahmed, S, Spurdle, AB, Otton, G., Dunning, AM, Czene, K, Burwinkel, B, Easton, DF, Liu, J, Sans, M., Otton, G, Healey, C.S., Teoman, A., Ruebner, M., Borresen-Dale, A.-L., Bolla, MK, French, JD, Werner, H.M.J., Carracedo, A., RENDOCAS, Ahmed, S., Painter, JN, Trovik, J., Cheng, T, Fridley, BL, Shu, X-O., Orr, N., Borresen-Dale, A-L., Marme, F, Painter, J.N., Winterhoff, B, Teoman, A, O'Mara, T.A., Australian Ovarian Cancer Study (AOCS), Lindblom, A., Consortium, CHIBCHA, Mints, M., Scott, R.J., Southey, M.C., Canc, N.S.E., Martin, NG, Gorman, M., Bolla, M.K., Shu, XO, Johnson, N, Chang-Claude, J, Amant, F, Bruinsma, F, Cunningham, JM, Olson, JE, Henders, A.K., Moisse, M, Castellvi-Bel, S., Pollock, P., Li, J, Hopper, J.L., Dennis, J, Cox, A, Ashton, K., Hall, P., Hillemanns, P., Weber, R.P., Depreeuw, J, Magdalena Echeverry De Polanco, M., Dork, T., Ekici, AB, Dürst, M, Brauch, H, Pharoah, P.D.P., Moisse, M., Network, GENICA, Dennis, J., Peto, J, Trovik, J, McEvoy, M, Edwards, SL, Lose, F.A., Xiang, Y-B., Goode, E.L., Lambrechts, D, Howarth, K, Teixeira, M.R., Kaufmann, S., Renner, SP, De Polanco, MME, Weber, RP, O'Mara, TA, Mints, M, Cunningham, J.M., AOCS, Jones, A., Gorman, M, Santos, E, Beckmann, M.W., Tomlinson, I, Fridley, B.L., Castellvi-Bel, S, Giles, GG, Dowdy, S.C., Schrauwen, S, Montgomery, GW, Martin, L., Xiang, Y.-B., Teixeira, MR, Tham, E, Wang, Q., Thompson, DJ, Proietto, T., Coenegrachts, L, GENICA Network, Cheng, T., Lindblom, A, Nyholt, D.R., Brenner, H., Attia, J, Li, J., Carvajal-Carmona, L., Long, J, Tzortzatos, G, Swerdlow, AJ, Pollock, P.M., Couch, FJ, Fasching, PA, Southey, MC, Meindl, A, Hillman, KM, Brauch, H., Moya, L., Burwinkel, B., Bruinsma, F., Howarth, K., French, J.D., Hodgson, S., Orr, N, Lose, FA, Scott, RJ, Børresen-Dale, AL, Czene, K., Pharoah, PD, Renner, S.P., Holliday, E., Hodgson, S, National Study of Endometrial Cancer Genetics Group (NSECG), Beckmann, MW, Kaufmann, S, Chen, Z., Martin, L, Walpole, C., Tyrer, JP, Shah, M., Healey, CS, Walpole, C.M., Brenner, H, Winterhoff, B., Hillman, K.M., Carvajal-Carmona, L, Kristensen, VN, Durst, M., Sans, M, Ashton, K, Duerst, M., Rojas-Martinez, A., Moya, L, Giles, G.G., Walpole, C, Jones, A, Xiang, YB, Cox, A., Tham, E., Runnebaum, I, Salvesen, HB, Werner, HMJ, Holliday, E, Peto, J., Couch, F.J., Carracedo, A, Hillemanns, P, Chen, Z, Depreeuw, J., Webb, P.M., Rudolph, A., Michailidou, K, Njolstad, T.S., Chang-Claude, J., Easton, D.F., Australian National Endometrial Cancer Study Group (ANECS), Thompson, D.J., Shah, M, Zheng, W, Edwards, S.L., Dieffenbach, A.K., Njolstad, TS, De Polanco, M.M.E., Dörk, T, Kristensen, V.N., Nyholt, DR, Goode, EL, Hein, A. +246 morecore +2 more sourcesAn Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions
Advanced Science, EarlyView.The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan +8 morewiley +1 more sourceA Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong +11 morewiley +1 more sourceEndometrial cancer and ultrasound: why measuring endometrial thickness is sometimes not enough [PDF]
Ultrasound in Obstetrics & Gynecology, 2011 AbstractEndometrial cancer is the commonest cancer of the female genital tract in the developed world. Ultrasound measurement of endometrial thickness is commonly used to triage patients with postmenopausal bleeding for histological sampling. The sensitivity of ultrasound in diagnosing endometrial cancer is high, but it has a small, well‐defined false ...J, Naftalin, N, Nunes, W, Hoo, R, Arora, D, Jurkovic +4 moreopenaire +2 more sourcesSAV1 in Cooperation With FKBP52 Participates in Implantation
Advanced Science, EarlyView.The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan +10 morewiley +1 more sourceReview of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT
Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.Camille Viaut, Valerie Cormier‐Dairewiley +1 more sourceBi-potential hPSC-derived Müllerian duct-like cells for full-thickness and functional endometrium regeneration
npj Regenerative Medicine, 2022 Stem cell-based tissue regeneration strategies are promising treatments for severe endometrial injuries. However, there are few appropriate seed cells for regenerating a full-thickness endometrium, which mainly consists of epithelia and stroma. Müllerian Lin Gong, Nanfang Nie, Xilin Shen, Jingwei Zhang, Yu Li, Yixiao Liu, Jiaqi Xu, Wei Jiang, Yanshan Liu, Hua Liu, Bingbing Wu, XiaoHui Zou +11 moredoaj +1 more source
