Results 181 to 190 of about 201,910 (397)

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan   +6 more
wiley   +1 more source

A head start: The relationship of placental factors to craniofacial and brain development

open access: yesDevelopmental Dynamics, EarlyView.
Abstract In recent years, the importance of placental function for fetal neurodevelopment has become increasingly studied. This field, known as neuroplacentology, has greatly expanded possible etiologies of neurodevelopmental disorders by exploring the influence of placental function on brain development.
Annemarie Jenna Carver   +2 more
wiley   +1 more source

Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology

open access: yesEye &ENT Research, EarlyView.
Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang   +9 more
wiley   +1 more source

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium.

open access: yesCell Reports, 2018
K. Suda   +14 more
semanticscholar   +1 more source

Mechanism of Borehole Stability in Fractured Formation With Discrete Fracture Network

open access: yesEnergy Science &Engineering, EarlyView.
ABSTRACT Due to the high degree of rock block dispersion and the extensive development of natural fractures in the fractured formation, the drilling fluid loss and wellbore instability accidents occur frequently during the drilling process. At present, in the numerical simulation research on wellbore stability in fractured formations, the randomness of
Shuxin Dong   +4 more
wiley   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner   +3 more
wiley   +1 more source

Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium

open access: yesDiagnostic Pathology, 2009
Background Different molecular alterations have been described in endometrioid endometrial carcinoma (EECA). Among them the most frequently altered is loss of the PTEN protein, a tumor suppressor gene.
Sotoudeh Kambiz   +3 more
doaj  

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