Results 41 to 50 of about 94,099 (313)

Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model

Reproductive Biology and Endocrinology, 2019
Background Endometriosis is the growth of uterine lining (endometrium) outside of the uterus. In other chronic inflammatory diseases, mitochondrial dysfunction is suspected of playing a role in disease pathogenesis.
Hannah M. Atkins, Manish S. Bharadwaj, Anderson O’Brien Cox, Cristina M. Furdui, Susan E. Appt, David L. Caudell   +5 more
doaj   +1 more source

Oestrogen and progestin responses in human endometrium [PDF]

, 2003
Our understanding of the mechanisms of the actions of oestrogens and progestins have evolved from the simple concept of nuclear receptor-mediated regulation of transcription to a highly sophisticated, finely tuned interplay between various coregulators ...
Verbost, P., P. Groothuis, P. Verbost, C. Punyadeera, Punyadeera, C., Groothuis, P.   +5 more
core   +1 more source

ADSC-derived exosomes-coupled decellularized matrix for endometrial regeneration and fertility restoration

Materials Today Bio, 2023
Endometrium is suspectable to severe injury due to recurrent abortion, curettage or intrauterine infection which could lead to pathological conditions and sabotage women's fertility.
Xiaoying Jin, Yangyang Dai, Liaobing Xin, Zi Ye, Jiayu Chen, Qianhong He, Xin Chen, Xiaodong Xu, Guanghui Song, Xiaohua Yu, Songying Zhang   +10 more
doaj   +1 more source

Impaired Expression of Membrane Type-2 and Type-3 Matrix Metalloproteinases in Endometriosis but Not in Adenomyosis

Diagnostics, 2022
Matrix metalloproteinases (MMPs) play an important role in menstruation and endometriosis; however, the membrane-type matrix metalloproteinases (MT-MMPs) are not well studied in endometriosis and adenomyosis.
Jane B. Maoga, Muhammad A. Riaz, Agnes N. Mwaura, Georgios Scheiner-Bobis, Ezekiel Mecha, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

TGF beta 1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways [PDF]

, 2010
Background: Decidualization (differentiation) of the endometrial stromal cells during the secretory phase of the menstrual cycle is essential for successful implantation.
Jones Marius, Philippa T K Saunders, Critchley, Hilary O. D., Kane, N.M., Hilary O D Critchley, Dey, Sudhansu Kumar, Kane Nicole M., Jan J Brosens, Marius Jones, Rodney W Kelly, Philippa T. K. Saunders, Jones, M., Kelly, Rodney W., Kane, Nicole M., Saunders Philippa T. K., Nicole M Kane, Jones, Marius, Brosens Jan J., Brosens, J.J., Kelly, R.W., Saunders, Philippa T. K., Jan J. Brosens, Hilary O. D. Critchley, Saunders, P.T.K., Brosens, Jan J., Saunders, Philippa T. K.; id_orcid, Critchley, H.O.D., Critchley Hilary O. D., Kelly Rodney W., Rodney W. Kelly, Nicole M. Kane   +30 more
core   +1 more source

Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Reproductive Biology and Endocrinology, 2021
Background Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumulative clinical pregnancy rate than ...
Marina M. Ziganshina, Nataliya V. Dolgushina, Galina V. Kulikova, Nafisa M. Fayzullina, Ekaterina L. Yarotskaya, Nailia R. Khasbiullina, Nigora F. Abdurakhmanova, Aleksandra V. Asaturova, Alexander I. Shchegolev, Alina A. Dovgan, Gennady T. Sukhikh   +10 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Squamous cell carcinoma endometrium [PDF]

, 2017
Primary pure squamous cell carcinoma (SCC) of endometrium is very rare. About 70 cases have been reported, according to WHO blue book. It is defined as a primary carcinoma of the endometrium composed of squamous cells of varying degree of differentiation.
Raina, Deepali, Nisha Marhatta, Deepali Raina, Marhatta, Nisha   +3 more
core   +2 more sources