Results 51 to 60 of about 160,423 (342)

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans [PDF]

, 2012
Type II endometrial carcinomas are a highly aggressive group of tumour subtypes that are frequently associated with inactivation of the TP53 tumour suppressor gene.
Athanassios Dellas, Aurelia Noske, Daniel Fink, Edge SB, Fadare O, Holger Moch, Ian J. Frew, Kristian Ikenberg, Markus Rechsteiner, Matthias Roessle, Niklaus Fankhauser, Peter J. Wild, Rosmarie Caduff, Silverberg SG, Strahil Georgiev, Tantbirojn P, Tashiro H, Thomas J. Fuchs, Tong GX, Wada H, Wilhelm Krek   +20 more
core   +4 more sources

Fine-tuned adaptation of embryo-endometrium pairs at implantation revealed by transcriptome analyses in Bos taurus.

PLoS Biology, 2019
Interactions between embryo and endometrium at implantation are critical for the progression of pregnancy. These reciprocal actions involve exchange of paracrine signals that govern implantation and placentation.
Fernando H Biase, Isabelle Hue, Sarah E Dickinson, Florence Jaffrezic, Denis Laloe, Harris A Lewin, Olivier Sandra   +6 more
doaj   +1 more source

Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients

Reproductive Biology and Endocrinology, 2010
Background Various endometrial abnormalities have been associated with luteal phase deficiency: a significant dyssynchrony in the maturation of the glandular epithelium and the stroma and a prevalence of out-of-phase endometrial biopsy specimens.
Irigoyen Marcela, Alfie Margarita, Vighi Susana, Olivares Carla, Meresman Gabriela F, Etchepareborda Juan J   +5 more
doaj   +1 more source

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques [PDF]

, 2020
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive ...
Agudelo, Marianna, Ardeshir, Amir, Balderes, Paul J., Bjorkman, Pamela J., Bournazos, Stylianos, Coffey, Lark L., Esswein, Shannon R., Gazumyanc, Anna, Immareddy, Ramya, Jurado, Andrea, Kapoor, Tania, Keeffe, Jennifer R., Keesler, Rebekah I., Lorenz, Ivo C., MacDonald, Margaret R., Nussenzweig, Michel C., Peace, Avery, Ravetch, Jeffrey V., Rice, Charles M., Robbiani, Davide F., Singapuri, Anil, Stuart, Jackson B., Usachenko, Jodie, Van Rompay, Koen K. A., Wang, Qiao, Watanabe, Jennifer   +25 more
core   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Effect of autologous platelet-rich plasma treatment on patients with thin endometrium

Revista Cubana de Medicina Militar, 2022
Introduction: The success of frozen embryo transfer cycles depends on a delicate interaction between embryo quality and endometrium. Low pregnancy rates are associated with a thin endometrium. Objective: To evaluate the effect of autologous platelet-rich
Tung Nguyen Thanh, Ai Hoang Van, Son Trinh The, Lan Do Ngoc, Hang Doan Thi, Trang Quan Van, Khoa Ba Tran, Sang Trieu Tien   +7 more
doaj   +2 more sources

Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-beta1 and bax genes

Reproductive Biology and Endocrinology, 2005
Background Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which do not survive in ectopic ...
Vega Margarita, Fuentes Ariel, Bacallao Ketty, Alves Alessandra, Torres Marisa, Johnson M Cecilia, Boric M Angélica   +6 more
doaj   +1 more source

Hyperbaric oxygen therapy: a possible choice for patients with resistant thin endometrium during frozen embryo transfer treatments

Reproductive Biology and Endocrinology, 2023
Background Thin endometrium is considered suboptimal for embryo implantation, leading to compromised pregnancy rates without effective therapies. While some studies have reported promoted endometrial growth after a period of hyperbaric oxygen therapy ...
Jingjing Chen, Fangling Huang, Jing Fu, Jianjuan Zhao, Jinsheng Li, Zhengrong Peng, Jing Zhao, Bin Xu, Shuyi Li, Qiong Zhang, Shaolin Liang, Yanping Li   +11 more
doaj   +1 more source