Results 71 to 80 of about 143,309 (313)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Collagen and Eosinophils in Jenny's Endometrium: Do They Differ With Endometrial Classification?

Frontiers in Veterinary Science, 2020
Collagen fibers and inflammatory cells are the basis for jenny endometrium Kenney and Doig's classification developed for the mare. The infiltration of a large number of eosinophils in the jenny endometrium is intriguing.
Jordi Miró, Miguel Gutiérrez-Reinoso, Joana Aguiar da Silva, Carina Fernandes, Maria Rosa Rebordão, Maria Rosa Rebordão, Graça Alexandre-Pires, Jaime Catalán, Graça Ferreira-Dias   +8 more
doaj   +1 more source

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]

Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema, Alves, Arsic, Asselin, Carluccio, Catov, Challis, Chen, Cheng, Cheng, Cheng, Cheng, Cherny, Chu, Crane, D.C. Wathes, D.R.E. Abayasekara, Flynn, Goncalves, Guillou, Herath, Jabbour, Karsch, Kim, Klein, Lamont, Lee, Leung, Lewis, Lunn, M. Elmes, Nielsen, Noble, Poyser, Reddy, Rimoldi, Robinson, S. Kirkup, Sharp, Smith, Smith, Thorburn, Villa, Wang, Wathes, Wendell, Whittle, Witkin, Z. Cheng, Zhang   +49 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Unique Molecular Features in High-Risk Histology Endometrial Cancers [PDF]

Endometrial cancer is the most common gynecologic malignancy in the United States and the sixth most common cancer in women worldwide. Fortunately, most women who develop endometrial cancer have low-grade early-stage endometrioid carcinomas, and simple ...
Collins, Kaitlyn, Hawkins, Shannon M., Jones, Devin E., Pandita, Pooja, Wang, Xiyin   +4 more
core   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Does pretrigger echogenic endometrium in assisted reproductive technology cycles reflect raised serum progesterone level?

Journal of Human Reproductive Sciences, 2018
Background: Serum progesterone is the main hormone of the luteal phase. The hyperechoic pattern of the endometrium in the luteal phase is believed to be induced by raised serum progesterone.
Monna Pandurangi, N Sanjeeva Reddy, G Usha Rani, Hepzibha Kirubamani   +3 more
doaj   +1 more source

Doppler ultrasound for prediction of IUCD-induced heavy menstrual bleeding: a prospective cohort study

The Egyptian Journal of Radiology and Nuclear Medicine, 2020
Background Previous studies reported changes in the local vasoactive substance production within the endometrium with a subsequent increase in vascularity as a possible mechanism of intrauterine contraceptive device (IUCD)-induced heavy menstrual ...
Mohamed S. Sweed, Khaled H. Swidan, Naira S. Ibrahim, Eman A. NasrElDin, Ihab A. Gomaa   +4 more
doaj   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

The relationship between endometrial thickness on the third day of cycle and the ovulation day

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2000
Objective: Infertility is a common health problem and its treatment is sometimes complicated by several factors. Endometrium thickness has been suggested as one of important predictor of uterine predisposition for pregnancy.
N Mousavi Far, N Mir Hoseini
doaj