Results 71 to 80 of about 143,576 (351)

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, EarlyView.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source

Enrichment of Hypermethylated DNA on Chip for Cervical Cancer Detection

Advanced Materials Interfaces, EarlyView.
A microfluidic chip coated with surface‐immobilized methyl binding domain 2 (MBD‐2) protein receptors, is able to bind hypermethylated DNA (hmDNA) from a cancer cell line selectively. Quantification by quantitative polymerase chain reaction (qPCR) shows a 30‐fold enrichment in cervical cancer target DNA.
Ruben W. Kolkman, Birgit M. M. Wever, Jeanne Elisabeth van Dongen, Annina P. van Splunter, Johan G. Bomer, Renske D. M. Steenbergen, Loes I. Segerink, Jurriaan Huskens   +7 more
wiley   +1 more source

The Role of Combined Treatment of Granulocyte Colony-stimulating Factor and Oestrogen in Treatment of Thin Endometrium: A Rat Model

Journal of Human Reproductive Sciences
Background: Thin endometrium, described as endometrial thickness below 7 mm on embryo transfer day in assisted reproduction cycles, is associated with decreased pregnancy rates.
Inci Kahyaoglu, Gülnur Take Kaplanoglu, Gökçe Nur Arik Erol, Serkan Kahyaoglu   +3 more
doaj   +1 more source

Fine-tuned adaptation of embryo-endometrium pairs at implantation revealed by transcriptome analyses in Bos taurus.

PLoS Biology, 2019
Interactions between embryo and endometrium at implantation are critical for the progression of pregnancy. These reciprocal actions involve exchange of paracrine signals that govern implantation and placentation.
Fernando H Biase, Isabelle Hue, Sarah E Dickinson, Florence Jaffrezic, Denis Laloe, Harris A Lewin, Olivier Sandra   +6 more
doaj   +1 more source

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-beta1 and bax genes

Reproductive Biology and Endocrinology, 2005
Background Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which do not survive in ectopic ...
Vega Margarita, Fuentes Ariel, Bacallao Ketty, Alves Alessandra, Torres Marisa, Johnson M Cecilia, Boric M Angélica   +6 more
doaj   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Effect of Zhuyun I Recipe Capsule Enema on the Immune Microenvironment of the Endometrium during Implantation Window in Rats [PDF]

, 2022
Hang Zhou, Guo Pei, Pengfei Zeng, Zhixing Yin, Yan Li, Jinzhu Huang, Yi Wang, Juan Li, Wanting Xia, Yang Wang, Chang Liu, Qian Zeng   +11 more
openalex   +1 more source

Hyperbaric oxygen therapy: a possible choice for patients with resistant thin endometrium during frozen embryo transfer treatments

Reproductive Biology and Endocrinology, 2023
Background Thin endometrium is considered suboptimal for embryo implantation, leading to compromised pregnancy rates without effective therapies. While some studies have reported promoted endometrial growth after a period of hyperbaric oxygen therapy ...
Jingjing Chen, Fangling Huang, Jing Fu, Jianjuan Zhao, Jinsheng Li, Zhengrong Peng, Jing Zhao, Bin Xu, Shuyi Li, Qiong Zhang, Shaolin Liang, Yanping Li   +11 more
doaj   +1 more source

A pilot study and case reports on endometrial microbiota and pregnancy outcome: An analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium

Reproductive Medicine and Biology, 2018
The present study aimed to analyze the pregnancy outcomes of IVF patients presenting Lactobacillus‐dominated microbiota (LDM) or non‐Lactobacillus‐dominated microbiota (NLDM) of their endometrium and to report cases who were treated for NLDM concurrently
K. Kyono, T. Hashimoto, Suguru Kikuchi, Y. Nagai, Y. Sakuraba   +4 more
semanticscholar   +1 more source